MSMB Human

Beta-Microseminoprotein Human Recombinant
Cat. No.
BT26094
Source
Escherichia Coli.
Synonyms
Beta-microseminoprotein, Prostate secreted seminal plasma protein, Prostate secretory protein PSP94, Seminal plasma beta-inhibin, Immunoglobulin-binding factor, MSP, PSP, PSP57, PSP94, PSP-94, MSP-beta, beta-MSP, Microseminoprotein, IGBF, PN44, MSMB, MSP-B, MSPB, PRPS, Prostatic Secretory Protein.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 95% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

MSMB Recombinant Human produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 104 amino acids and having a molecular mass of 12 kDa.
The MSMB is fused to His tag at N-Terminus.
The Human MSMB is purified by proprietary chromatographic techniques.

Product Specs

Introduction
Microseminoprotein, a member of the immunoglobulin binding factor family, is produced by prostate gland epithelial cells and secreted into seminal plasma. Exhibiting inhibin-like activity, this protein may function as an autocrine/paracrine factor in female reproductive tissues like the uterus and breasts. Notably, its expression is reduced in prostate cancer. This gene is known to have two alternatively spliced transcript variants that encode distinct isoforms, and the use of alternative polyadenylation sites has been observed.
Description
Recombinant Human MSMB, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 104 amino acids. With a molecular weight of 12 kDa, this MSMB variant features a His tag fused at the N-terminus. Purification is achieved through proprietary chromatographic techniques.
Physical Appearance
White, sterile, lyophilized powder.
Formulation
The protein solution, sterile-filtered and concentrated to 0.5mg/ml, was lyophilized with 20mM Tris and 20mM NaCl at a pH of 7.5.
Solubility
To create a working solution of 0.5mg/ml, add deionized water to the lyophilized pellet and allow it to dissolve completely.
Stability
Store the lyophilized protein at -20°C. After reconstitution, aliquot the product to minimize freeze-thaw cycles. Reconstituted protein can be stored at 4°C for a limited period.
Purity
Purity exceeds 95% as determined by SDS-PAGE analysis.
Synonyms
Beta-microseminoprotein, Prostate secreted seminal plasma protein, Prostate secretory protein PSP94, Seminal plasma beta-inhibin, Immunoglobulin-binding factor, MSP, PSP, PSP57, PSP94, PSP-94, MSP-beta, beta-MSP, Microseminoprotein, IGBF, PN44, MSMB, MSP-B, MSPB, PRPS, Prostatic Secretory Protein.
Source
Escherichia Coli.
Amino Acid Sequence
MKHHHHHHAS SCYFIPNEGV PGDSTRKCMD LKGNKHPINS EWQTDNCETC TCYETEISCC TLVSTPVGYD KDNCQRIFKK EDCKYIVVEK KDPKKTCSVSEWII.

Product Science Overview

Gene and Protein Structure

The MSMB gene is located on chromosome 10 (10q11.22) in humans . The protein encoded by this gene belongs to the immunoglobulin binding factor family and has inhibin-like activity . The MSMB protein consists of 94 amino acids and has a molecular weight of approximately 10 kDa .

Evolution and Function

MSMB is a rapidly evolving protein, which can be attributed to either sexual selection or innate pathogen defense . The wide distribution of MSMB in the body and its fungicidal properties suggest that innate pathogen defense plays a significant role in its evolution . The C-terminus domain of MSMB contains two two-stranded β-sheets, which have no resemblance to other structural motifs .

Biological Role and Expression

MSMB is secreted by epithelial cells in various organs, including the liver, lung, breast, kidney, colon, stomach, pancreas, esophagus, duodenum, salivary glands, fallopian tube, corpus uteri, bulbourethral glands, and cervix . This widespread expression corresponds closely to the sites from which all late-onset cancers develop .

In the prostate, MSMB is thought to play a role as an autocrine/paracrine factor in regulating prostate function and growth . The expression of MSMB is found to be decreased in prostate cancer, suggesting its potential role as a tumor suppressor .

Clinical Significance

Due to its significant role in prostate biology and its altered expression in prostate cancer, MSMB has been studied as a potential biomarker for prostate cancer diagnosis and prognosis . Additionally, recombinant MSMB has been explored for its therapeutic potential in treating prostate cancer and other conditions related to its biological functions.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.