PSMG2 Human
Proteasome assembly chaperone 2, PAC-2, Hepatocellular carcinoma-susceptibility protein 3, Tumor necrosis factor superfamily member 5-induced protein 1, PSMG2, HCCA3, PAC2, TNFSF5IP1, CLAST3, MDS003, HsT1707, MGC15092.
Description
PSMG2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-264 a.a.) and having a molecular mass of 31.8kDa.
PSMG2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Proteasome assembly chaperone 2, PAC-2, Hepatocellular carcinoma-susceptibility protein 3, Tumor necrosis factor superfamily member 5-induced protein 1, PSMG2, HCCA3, PAC2, TNFSF5IP1, CLAST3, MDS003, HsT1707, MGC15092.
MGSSHHHHHH SSGLVPRGSH MGSMFVPCGE SAPDLAGFTL LMPAVSVGNV GQLAMDLIIS TLNMSKIGYF YTDCLVPMVG NNPYATTEGN STELSINAEV YSLPSRKLVA LQLRSIFIKY KSKPFCEKLL SWVKSSGCAR VIVLSSSHSY QRNDLQLRST PFRYLLTPSM QKSVQNKIKS LNWEEMEKSR CIPEIDDSEF CIRIPGGGIT KTLYDESCSK EIQMAVLLKF VSEGDNIPDA LGLVEYLNEW LQILKPLSDD PTVSASRWKI PSSWRLLFGS GLPPALF.
Product Science Overview
PSMG2 functions as part of a heterodimer with PSMG1 (PAC1). The PSMG1-PSMG2 heterodimer binds to the proteasome subunits PSMA5 and PSMA7, promoting the assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and preventing alpha ring dimerization . This chaperone-mediated assembly ensures the correct formation of the proteasome core particle, which is vital for its proteolytic activity.
The assembly of the 20S proteasome involves several steps, with PSMG2 playing a key role in the early stages. The heterodimeric chaperone pairs, including PSMG1-PSMG2, assist in the formation of the alpha-ring, which serves as a template for the incoming beta-subunits . This process is tightly regulated to ensure the proper assembly and function of the proteasome complex.
The proteasome complex is essential for various cellular processes, including the regulation of the cell cycle, apoptosis, and response to oxidative stress. By facilitating the assembly of the 20S proteasome, PSMG2 indirectly influences these critical cellular functions. Dysregulation of proteasome assembly can lead to various diseases, including neurodegenerative disorders and cancers .
Mutations or alterations in the expression of PSMG2 have been associated with diseases such as Proteasome-Associated Autoinflammatory Syndrome 4 and Cyclic Neutropenia . Understanding the role of PSMG2 in proteasome assembly can provide insights into the pathogenesis of these diseases and potentially lead to the development of targeted therapies.
Research on PSMG2 and its role in proteasome assembly continues to be an active area of study. The development of recombinant PSMG2 proteins has enabled detailed investigations into its structure and function, providing valuable information for drug discovery and therapeutic interventions.
