PSMD9 Human
Description
Product Specs
Product Science Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator . The 20S core consists of four rings of 28 non-identical subunits, while the 19S regulator is composed of a base containing six ATPase subunits and two non-ATPase subunits, and a lid containing up to ten non-ATPase subunits . PSMD9 is one of the non-ATPase subunits of the 19S regulator .
Proteasomes are distributed throughout eukaryotic cells at high concentrations and are essential for the ATP/ubiquitin-dependent process of protein degradation in a non-lysosomal pathway . An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides . PSMD9 has been implicated in various cellular processes, including transcription coactivator activity and bHLH transcription factor binding .
PSMD9 has been associated with several diseases, including deafness, autosomal recessive 62 and esophagus melanoma . Recent studies have shown that PSMD9 promotes the malignant progression of hepatocellular carcinoma (HCC) by interacting with c-Cbl to activate EGFR signaling and recycling . The expression of PSMD9 is correlated with recurrence and radiotherapy resistance in several tumor types . Knockdown of PSMD9 has been shown to inhibit HCC cell proliferation by inducing G1/S cell cycle arrest and apoptosis .
Given its role in protein homeostasis and disease progression, PSMD9 is a potential therapeutic target for various cancers, including HCC . Research is ongoing to better understand the mechanisms by which PSMD9 influences cancer progression and to develop targeted therapies that can inhibit its function .
