PRTFDC1 Human
Phosphoribosyltransferase domain-containing protein 1, PRTFDC1, HHGP.
Description
PRTFDC1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 248 amino acids (1-225 a.a.) and having a molecular mass of 28.1kDa.
PRTFDC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Phosphoribosyltransferase domain-containing protein 1, PRTFDC1, HHGP.
MGSSHHHHHH SSGLVPRGSH MGSMAGSSEE APDYGRGVVI MDDWPGYDLN LFTYPQHYYG DLEYVLIPHG IIVDRIERLA KDIMKDIGYS DIMVLCVLKG GYKFCADLVE HLKNISRNSD RFVSMKVDFI RLKSYRNDQS MGEMQIIGGD DLSTLAGKNV LIVEDVVGTG RTMKALLSNI EKYKPNMIKV ASLLVKRTSR SDGFRPDYAG FEIPNLFVVG YALDYNEYFR DLNHICVINE HGKEKYRV.
Product Science Overview
PRTFDC1 is a protein-coding gene that has been associated with several biological processes and molecular functions. The protein encoded by this gene has low, barely detectable phosphoribosyltransferase activity in vitro. It binds guanosine monophosphate (GMP), inosine monophosphate (IMP), and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP) . Despite its structural similarity to hypoxanthine-guanine phosphoribosyltransferase (HPRT), PRTFDC1 is not expected to contribute significantly to purine metabolism or GMP salvage .
The structure of PRTFDC1 has been determined at a resolution of 1.7 Å with bound GMP . The overall structure and GMP binding mode are very similar to that observed for HPRT. However, the catalytic efficiency of PRTFDC1 towards hypoxanthine and guanine is significantly lower than that of HPRT . This low activity is attributed to the presence of a glycine residue in the position of the proposed catalytic aspartate of HPRT .
PRTFDC1 is predicted to be involved in the purine ribonucleoside salvage pathway, although its exact biological function remains unclear . It has been suggested that PRTFDC1 may play a role in certain physiological conditions and diseases. For instance, it has been associated with auditory neuropathy, autosomal dominant 3, and physiological polycythemia . Additionally, recent studies have indicated a potential involvement of PRTFDC1 in the development of ovarian cancer .
