PRPS2 Human
Description
Product Specs
Phosphoribosyl Pyrophosphate Synthetase 2, also known as PRPS2, is an enzyme that plays a crucial role in nucleotide biosynthesis. It belongs to the ribose-phosphate pyrophosphokinase family and is responsible for catalyzing the formation of 5-phosphoribosyl 1-pyrophosphate (PRPP) from ATP and D-ribose 5-phosphate. PRPP is a key precursor molecule in the synthesis of purine and pyrimidine nucleotides, which are essential building blocks of DNA and RNA.
Product Science Overview
PRPS2 catalyzes the conversion of ribose-5-phosphate (R5P) into phosphoribosyl pyrophosphate (PRPP) by transferring pyrophosphate groups from ATP to R5P . This reaction is essential for the synthesis of purine and pyrimidine nucleotides, as well as certain amino acids like histidine and tryptophan . The enzyme’s activity links the pentose phosphate pathway, which produces R5P, to nucleotide biosynthesis .
PRPS2 exists as a hexamer, formed by three homodimers . The enzyme’s structure has been elucidated through crystallization and X-ray diffraction studies, revealing the binding regions for R5P and ATP . The enzyme’s active form is a complex of these hexamers, which are regulated by allosteric inhibitors such as ADP .
Mutations or dysregulation of PRPS2 can lead to various metabolic disorders. For instance, overactivity of PRPS2 is associated with increased nucleotide synthesis, which can contribute to the rapid proliferation of cancer cells . Conversely, deficiencies in PRPS2 activity can impair nucleotide synthesis, affecting DNA and RNA production and leading to developmental and metabolic issues .
