PRMT1 Mouse
Description
The PRMT1 is purified by proprietary chromatographic techniques.
Product Specs
VNKDKPLGAV ALKSYEEELA KDPRIAATME NAQKGEIMPN IPQMSAFWYA VRTAVINAAS GRQTVDEALK DAQTNSSSNN NNNNNNNNLG IEGRGSHMAA AEAANCIMEV SCGQAESSEK PNAEDMTSKD YYFDSYAHFG IHEEMLKDEV RTLTYRNSMF HNRHLFKDKV VLDVGSGTGILCMFAAKAGA RKVIGIECSS ISDYAVKIVK ANKLDHVVTI IKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVLHAR DKWLAPDGLI FPDRATLYVT AIEDRQYKDY KIHWWENVYG
FDMSCIKDVA IKEPLVDVVD PKQLVTNACL IKEVDIYTVK VEDLTFTSPF CLQVKRNDYVHALVAYFNIE FTRCHKRTGF STSPESPYTH WKQTVFYMED YLTVKTGEEI FGTIGMRPNA KNNRDLDFTI DLDFKGQLCE LSCSTDYRMR.
Product Science Overview
Protein Arginine Methyltransferase 1 (PRMT1) is a member of the protein arginine methyltransferase family, which plays a crucial role in the post-translational modification of proteins. PRMT1 is the predominant arginine methyltransferase in mammals, responsible for more than 85% of the arginine methylation activity in cells . This enzyme is involved in various cellular processes, including transcriptional regulation, RNA processing, DNA repair, and signal transduction .
PRMT1 catalyzes the transfer of methyl groups from S-adenosylmethionine (AdoMet) to the guanidine nitrogen atoms of arginine residues in target proteins, forming monomethylarginine and asymmetric dimethylarginine . This methylation process increases the structural diversity of proteins and modulates their function within the cell .
PRMT1 is a type-I methyltransferase that specifically targets histone H4 in eukaryotic cells, altering its structure and enabling chromatin remodeling . This modification is essential for the regulation of gene expression and maintenance of genomic integrity .
PRMT1 is critical for various biological processes, including:
- Transcriptional Regulation: PRMT1 acts as a transcriptional co-activator by methylating histones and other transcription factors, thereby influencing gene expression .
- RNA Processing: PRMT1 is involved in the regulation of RNA splicing and processing by methylating RNA-binding proteins .
- DNA Repair: PRMT1 plays a role in the DNA damage response by methylating proteins involved in DNA repair pathways .
- Signal Transduction: PRMT1 modulates signal transduction pathways by methylating signaling proteins .
In mouse models, PRMT1 has been shown to regulate various physiological processes. For instance, PRMT1 is essential for the development and homeostasis of enteroendocrine cells in the adult intestinal epithelium . Enteroendocrine cells are hormone-producing cells that play a crucial role in energy homeostasis and metabolism . PRMT1 deficiency in mice leads to an increase in the number of enteroendocrine cells and upregulation of enteroendocrine-specific hormones and transcription factors .
