PRDX2 Human
Peroxiredoxin-2 Human Recombinant
Cat. No.
BT24952
Source
Escherichia Coli.
Synonyms
PRP, TSA, PRX2, NKEFB, PRXII, TDPX1, MGC4104, PRDX2, Peroxiredoxin-2, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Thiol-specific antioxidant protein, Natural killer cell-enhancing factor B, NKEF-B.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
PRDX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 198 amino acids and having a molecular mass of 21.8 kDa.
The PRDX2 is purified by proprietary chromatographic techniques.
The PRDX2 is purified by proprietary chromatographic techniques.
Product Specs
Introduction
PRDX2, a member of the peroxiredoxin family, functions as an antioxidant enzyme by reducing hydrogen peroxide and alkyl hydroperoxides. It plays a crucial role in cellular antioxidant defense and contributes to the antiviral activity of CD8(+) T-cells. Additionally, PRDX2 has been implicated in cancer development or progression due to its proliferative effects. Insufficient PRDX2 protection against peroxidases can lead to DNA damage, potentially resulting in neurological disorders like Alzheimer's disease or cancer.
Description
Recombinant human PRDX2, expressed in E. coli, is a non-glycosylated polypeptide chain with a molecular weight of 21.8 kDa, consisting of 198 amino acids. The protein is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
The PRDX2 solution is supplied in a buffer containing 20mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. To ensure optimal stability during long-term storage, the addition of a carrier protein (0.1% HSA or BSA) is advised. Repeated freezing and thawing should be avoided.
Purity
The purity of the protein is greater than 90% as determined by SDS-PAGE analysis.
Biological Activity
The specific activity of the enzyme is estimated to be between 200 and 230 picomoles of hydroperoxide reduced per minute per microgram of protein. The enzymatic activity was assessed by quantifying the remaining peroxide concentration after incubating PRDX2 with peroxide for 20 minutes at room temperature. Specific activity is defined as the amount of hydroperoxide reduced by 1 microgram of enzyme per minute at 25°C.
Synonyms
PRP, TSA, PRX2, NKEFB, PRXII, TDPX1, MGC4104, PRDX2, Peroxiredoxin-2, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, Thiol-specific antioxidant protein, Natural killer cell-enhancing factor B, NKEF-B.
Source
Escherichia Coli.
Amino Acid Sequence
MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN.
Product Science Overview
Structure and Function
Prdx2 is the third most abundant protein in erythrocytes (red blood cells) . It was previously known as calpromotin due to its ability to bind to the membrane and stimulate the calcium-dependent potassium channel . Prdx2 is primarily found in the cytosol as non-covalent dimers but can also form doughnut-like decamers and other oligomers .
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