PPIL4 Human
Description
Product Specs
MGSSHHHHHH SSGLVPRGSH MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIIKKIN ETFVDKDFVP YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTREQLDSGR IGADEEIDDF KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPPNLV LKDKVKPKQD TKYDLILDEQ AEDSKSSHSH TSKKHKKKTH HCSEEKEDED YMPIKNTNQD IYREMGFGHY EEEESCWEKQ KSEKRDRTQN RSRSRSRERD GHYSNSHKSK YQTDLYERER SKKRDRSRSP KKSKDKEKSK YR.
Product Science Overview
Peptidylprolyl isomerases (PPIases) are a family of enzymes that catalyze the cis-trans isomerization of proline imidic peptide bonds in proteins, which is a critical step in protein folding. Cyclophilins are a subset of PPIases and are known for their role in protein folding, immunosuppression, and various cellular processes.
Cyclophilin-Like 4 (CYP4) is a member of the cyclophilin family. While the specific functions of CYP4 are not as well-characterized as other cyclophilins, it shares the common structural and functional features of the family. Cyclophilins, including CYP4, are involved in protein folding, trafficking, and immune regulation.
Recombinant proteins are proteins that are artificially produced through recombinant DNA technology. Human recombinant Cyclophilin-Like 4 (CYP4) is produced by inserting the gene encoding CYP4 into an expression system, such as bacteria or yeast, which then produces the protein. This allows for the study and utilization of CYP4 in various research and therapeutic applications.
Cyclophilins, including CYP4, play a role in:
- Protein Folding: Catalyzing the cis-trans isomerization of proline residues, which is essential for proper protein folding.
- Immunosuppression: Cyclophilins are known to bind to immunosuppressive drugs like cyclosporin A, which inhibits calcineurin and prevents T-cell activation.
- Cellular Processes: Involvement in various cellular processes such as signal transduction, apoptosis, and cell proliferation.
Cyclophilins are ubiquitously expressed in various tissues. The expression patterns of CYP4 specifically are not well-documented, but it is likely to be expressed in multiple tissues similar to other cyclophilins.
Recombinant human CYP4 can be used in research to study its structure, function, and interactions with other proteins. It may also have potential therapeutic applications, such as in the development of immunosuppressive therapies or treatments for diseases involving protein misfolding.
