PPIC Antibody

Peptidylprolyl Isomerase C (PPIC), also known as Cyclophilin C, is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. These enzymes catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, which is crucial for protein folding and function .

PPIC is a protein-coding gene that plays a significant role in protein folding by accelerating the isomerization of peptide bonds at proline residues. This activity is essential for the proper folding of many proteins, which in turn affects their stability and function . PPIC is also involved in various cellular processes, including signal transduction, cell cycle regulation, and immune response.

PPIC has been shown to interact with several proteins involved in the immune response. It is a cyclosporin-binding protein, which means it can bind to the immunosuppressive drug cyclosporin A. This interaction is crucial for cyclosporin A-mediated immunosuppression, which is often used in organ transplantation to prevent rejection .

Mouse anti-human PPIC antibodies are monoclonal antibodies produced by immunizing mice with human PPIC protein. These antibodies are used in various research applications, including Western blotting, immunoprecipitation, and immunofluorescence. They are valuable tools for studying the expression and function of PPIC in different biological contexts .

Research on PPIC has significant implications for understanding various diseases and developing therapeutic strategies. For instance, PPIC’s role in protein folding and immune response makes it a potential target for drug development in conditions like cancer, neurodegenerative diseases, and autoimmune disorders .