PLAC8 Human
Description
PLAC8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The PLAC8 protein contains five exons, coding for an mRNA species of 829 base pairs and an open reading frame of 115 amino acids . This protein shows a high degree of conservation (83%) between humans and mice . PLAC8 is expressed at high levels in various tissues, including plasmacytoid dendritic cells, spleen, lymph nodes, peripheral blood leukocytes, and bone marrow .
PLAC8 plays multifaceted roles in both normal physiological processes and pathological conditions:
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Pregnancy and Placental Development: PLAC8 expression is dynamic during pregnancy and placental development, accumulating in an implantation-dependent manner . It is highly expressed in the endometrium of pregnant cows compared to nonpregnant cows and is upregulated in blastocysts, contributing to calf delivery .
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Embryo Development: PLAC8 is involved in the differentiation process of cytotrophoblast cells into interstitial extravillous trophoblast cells . It has been found to be involved in organ development and is a molecular marker to predict prognosis and distinguish between different cell subpopulations .
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Cancer: The role of PLAC8 in tumorigenesis has been gradually elucidated. It impacts tumorigenesis in varied ways, sometimes having opposite effects on cancer progression . PLAC8’s molecular functions in cancer include enforcing cell growth and influencing different stages of cancer progression . Understanding these roles can lead to the development of novel anticancer therapies .
Recombinant human PLAC8 protein, fused to a His-tag at the N-terminus, is expressed in E. coli . This recombinant protein is used for research purposes and is not approved for clinical use in humans . It is typically used in Western Blot (WB) or imaging assays .
Storage and Handling: The recombinant human PLAC8 protein should be stored at 4°C for short-term use and at -20°C for long-term storage. It is important to avoid freeze-thaw cycles to maintain its stability .
