PIN1 Antibody

PIN1 (Peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1) is a unique enzyme that plays a crucial role in regulating protein function through post-phosphorylation control. This enzyme is encoded by the PIN1 gene and is involved in various cellular processes, including cell division, proliferation, and survival .

PIN1 is a small protein with a molecular weight of approximately 18 kDa. It specifically binds to phosphorylated serine/threonine-proline (pSer/Thr-Pro) motifs and catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds . This conformational change in target proteins acts as a molecular switch, influencing multiple cellular processes such as mitosis, kinase activity, oncogene activation, and cell transformation .

PIN1 is essential for the regulation of cell growth, stress responses, immune response, and neuronal differentiation . It has been implicated in the pathogenesis of several diseases, including Alzheimer’s disease and various cancers . The enzyme’s activity is regulated by phosphorylation, and its expression is often associated with cell proliferation .

Mouse anti-human PIN1 antibodies are widely used in scientific research to study the expression and function of PIN1 in various biological samples. These antibodies are developed in mice and are specific to the human PIN1 protein . They are commonly used in applications such as Western Blot, Immunohistochemistry, ELISA, Immunoprecipitation, and Immunocytochemistry .

1. Western Blot: Detects PIN1 protein levels in cell and tissue lysates.
2. Immunohistochemistry: Localizes PIN1 expression in tissue sections.
3. ELISA: Quantifies PIN1 protein levels in various samples.
4. Immunoprecipitation: Isolates PIN1 protein for further analysis.
5. Immunocytochemistry: Visualizes PIN1 expression in cultured cells .