PDRG1 Human
Description
Product Specs
MGSSHHHHHH SSGLVPRGSH MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD LSLSEDVMVC FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN RLFEAQGKPE LKGFNLNPLN QDELKALKVI LKG.
Product Science Overview
The p53 protein, often referred to as the “guardian of the genome,” plays a crucial role in maintaining cellular integrity by regulating the cell cycle and preventing genomic mutations. It is a tumor suppressor protein that responds to various cellular stresses to induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. The DNA-Damage Regulated 1 (PDRG1) protein, also known as p53 and DNA-Damage Regulated 1, is a protein coding gene that is regulated by p53 and is involved in the cellular response to DNA damage.
The p53 protein is encoded by the TP53 gene located on chromosome 17p13.1. It is a transcription factor that regulates the expression of a wide array of genes involved in cell cycle control, apoptosis, DNA repair, and other critical cellular processes. Upon DNA damage, p53 is stabilized and activated through post-translational modifications such as phosphorylation and acetylation. Activated p53 can induce the expression of genes that halt the cell cycle, allowing time for DNA repair or triggering apoptosis if the damage is irreparable .
PDRG1, also known as p53 and DNA-Damage Regulated 1, is a protein coding gene that is regulated by p53. It is located on chromosome 20 and is involved in protein folding and the cellular response to DNA damage. PDRG1 is predicted to enable unfolded protein binding activity and is part of the prefoldin complex, which assists in the proper folding of newly synthesized proteins .
The interaction between p53 and PDRG1 is crucial for the cellular response to DNA damage. Upon DNA damage, p53 is activated and can induce the expression of PDRG1. PDRG1, in turn, plays a role in chaperone-mediated protein folding, ensuring that proteins are correctly folded and functional. This interaction helps maintain cellular homeostasis and prevents the propagation of damaged DNA .
Mutations in the TP53 gene are among the most common alterations in human cancers, highlighting the importance of p53 in tumor suppression. The loss of p53 function can lead to uncontrolled cell proliferation and tumor development. Understanding the role of p53 and its regulated proteins, such as PDRG1, is essential for developing targeted cancer therapies. Research into the p53-PDRG1 pathway may provide insights into novel therapeutic strategies for cancer treatment .
