PAX9 Human
Paired Box 9 Human Recombinant
Cat. No.
BT2642
Source
Escherichia Coli.
Synonyms
Paired Box 9, STHAG3, Paired Box Gene 9, Paired Box Protein Pax-9, Paired Domain Gene 9.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
PAX9 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 364 amino acids (1-341 a.a) and having a molecular mass of 38.7kDa.
PAX9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PAX9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
PAX9 (Paired box protein Pax-9) is a transcription factor that belongs to the paired box (PAX) family. PAX9 family members typically have a paired box domain, an octapeptide, and a paired-type homeodomain. These genes are essential for fetal development and cancer growth. Furthermore, PAX9 is crucial for developing various organs and skeletal elements.
Description
Recombinant human PAX9, expressed in E. coli, is a single, non-glycosylated polypeptide chain containing 364 amino acids (1-341 a.a) with a molecular weight of 38.7 kDa. It is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
The product is a clear solution that has been sterilized by filtration.
Formulation
The PAX9 protein solution is supplied at a concentration of 1 mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 0.4M Urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For longer storage periods, it is recommended to store the product frozen at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Repeated freezing and thawing of the product should be avoided.
Purity
The purity of the PAX9 protein is greater than 85.0% as determined by SDS-PAGE analysis.
Synonyms
Paired Box 9, STHAG3, Paired Box Gene 9, Paired Box Protein Pax-9, Paired Domain Gene 9.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEPAFGE VNQLGGVFVN GRPLPNAIRL RIVELAQLGI RPCDISRQLR VSHGCVSKIL ARYNETGSIL PGAIGGSKPR VTTPTVVKHI RTYKQRDPGI FAWEIRDRLL ADGVCDKYNV PSVSSISRIL RNKIGNLAQQ GHYDSYKQHQ PTPQPALPYN HIYSYPSPIT AAAAKVPTPP GVPAIPGSVA MPRTWPSSHS VTDILGIRSI TDQVSDSSPY HSPKVEEWSS LGRNNFPAAA PHAVNGLEKG ALEQEAKYGQ APNGLPAVGS FVSASSMAPY PTPAQVSPYM TYSAAPSGYV AGHGWQHAGG TSLSPHNCDI PASLAFKGMQ AAREGSHSVT ASAL.
Product Science Overview
Structure and Function
PAX9 functions as an RNA Polymerase II transcription factor, regulating the expression of proteins required for craniofacial and tooth development in humans . It also plays a role in ribosome biogenesis, which is crucial for protein synthesis . Dysregulation of ribosome production can lead to developmental disorders known as ribosomopathies, which often manifest in a tissue-specific manner .
Recombinant PAX9
Recombinant human PAX9 protein is typically produced in E. coli and is fused to a His-tag at the N-terminus . This recombinant protein is used for research purposes to study its role in development and disease. The protein is denatured and purified to a high degree, with a purity greater than 85% as determined by SDS-PAGE .
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