PALM Human

Paralemmin is predominantly expressed in the brain, where it is involved in the formation and maintenance of neuronal processes. It is also expressed in other tissues, including the retina and lens, where it plays a role in membrane formation and cell differentiation . In the retina, Paralemmin expression is transiently upregulated during the formation of the optic nerve and the inner and outer plexiform layers .

Recombinant Human Paralemmin-1 protein is a full-length human protein expressed in Escherichia coli. It is typically used in research applications such as SDS-PAGE and mass spectrometry (MS). The recombinant protein is purified using conventional chromatography techniques and has a purity of over 85% .

Paralemmin-1 has been found to be over-expressed in estrogen-receptor-positive breast cancer, suggesting a potential role in cancer cell motility and metastasis . This makes it a protein of interest in cancer research, particularly in understanding the mechanisms of cancer cell spread and identifying potential therapeutic targets.

Due to its role in plasma membrane dynamics and cell process formation, Paralemmin is a valuable protein in various research fields, including neuroscience, ophthalmology, and cancer research. Its ability to drive membrane formation and process outgrowth makes it a key player in studies related to neuronal development and differentiation .