PAIP2 Human
Polyadenylate-Binding Protein-Interacting protein 2 Human Recombinant
Cat. No.
BT4579
Source
Escherichia Coli.
Synonyms
Poly(A) Binding Protein Interacting Protein 2, PABP- interacting protein 2, HSPC218, PAIP-2, PAIP2A, Polyadenylate-binding protein-interacting protein 2, PAIP2, MGC72018.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Recombinant Human PAIP2 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 147 amino acids (1-127 a.a.) and having a molecular mass of 17.1 kDa.
PAIP2 human recombinant is fused to 20 amino acid His Tag at N-terminus and purified by convential chromatogrpahy techniques.
PAIP2 human recombinant is fused to 20 amino acid His Tag at N-terminus and purified by convential chromatogrpahy techniques.
Product Specs
Introduction
PAIP2 acts as a repressor in the initiation of translation for poly(A)-containing mRNAs. It inhibits translation by acting on PABPC1, disrupting its interaction with poly(A) RNA. PAIP2 competes with PAIP1 to bind with PABPC1. When PAIP2 binds to PABPC1, it disrupts the cytoplasmic poly(A) RNP structure organization.
Description
Recombinant Human PAIP2, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 147 amino acids (amino acids 1-127). It has a molecular mass of 17.1 kDa. This recombinant PAIP2 is fused to a 20 amino acid His Tag at the N-terminus and is purified using standard chromatographic techniques.
Physical Appearance
Sterile, colorless solution free of particles.
Formulation
The PAIP2 protein solution is formulated in 20mM Tris-HCl buffer with a pH of 8, 1mM DTT, and 10% Glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For longer storage, freeze at -20°C. Adding a carrier protein like 0.1% HSA or BSA is recommended for long-term storage. Avoid repeatedly freezing and thawing.
Purity
Purity is greater than 90% as determined by SDS-PAGE analysis.
Synonyms
Poly(A) Binding Protein Interacting Protein 2, PABP- interacting protein 2, HSPC218, PAIP-2, PAIP2A, Polyadenylate-binding protein-interacting protein 2, PAIP2, MGC72018.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP GVKYGNI.
Product Science Overview
Structure and Function
PAIP2 acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on Poly(A)-Binding Protein Cytoplasmic 1 (PABPC1). PAIP2 displaces the interaction of PABPC1 with poly(A) RNA and competes with Polyadenylate-Binding Protein-Interacting Protein 1 (PAIP1) for binding to PABPC1 . This interaction results in the disruption of the cytoplasmic poly(A) ribonucleoprotein (RNP) structure organization .
Biological Pathways
Gene and Protein Information
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