Osteocrin Human, HEK
HEK293 Cells.
Osteocrin, Musclin, OSTN.
Greater than 95.0% as determined by SDS-PAGE.
Description
Osteocrin Human Recombinant is a single, glycosylated, polypeptide chain (28-133 a.a) containing a total of 112 amino acids and having a molecular mass of 12.5 kDa.
Osteocrin is fused to a 6 a.a His-Tag at C-terminus and is purified by proprietary chromatographic techniques.
Product Specs
Osteocrin, Musclin, OSTN.
HEK293 Cells.
VDVTTTEAFD SGVIDVQSTP TVREEKSATD LTAKLLLLDE LVSLENDVIE TKKKRSFSGF GSPLDRLSAG SVDHKGKQRK VVDHPKRRFG IPMDRIGRNR LSNSRGHHHH HH.
Product Science Overview
Osteocrin, also known as Musclin, is a small secreted protein primarily expressed in bone and muscle tissues. It is synthesized as a proprotein and undergoes proteolytic processing to generate a mature peptide . This protein has garnered significant interest due to its multifaceted roles in various physiological processes, including bone growth, muscle function, and cardiovascular health.
Osteocrin was initially identified using a viral-based signal-trap strategy targeting the bone "secretome" . The gene encoding Osteocrin produces a mature protein of 103 amino acids with a molecular mass of approximately 11.4 kDa . It shares homology with members of the natriuretic peptide (NP) family, particularly in its ability to bind to the NPR-C receptor .
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Bone Growth and Development: Osteocrin plays a crucial role in bone growth by modulating the actions of the natriuretic system. It binds specifically to the NPR-C receptor, which helps in locally elevating levels of C-type natriuretic peptide (CNP), thereby promoting bone growth . Overexpression of Osteocrin in transgenic mice has been shown to result in elongated bones and increased bone length .
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Muscle Function: As a myokine, Osteocrin is involved in regulating muscle function and physical endurance. It is activity-stimulated and has been implicated in various muscle-related processes .
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Cardiovascular Health: Osteocrin has been shown to have cardioprotective effects, particularly in the context of diabetic cardiomyopathy (DCM). It helps restore proteasomal activity, which is often compromised in diabetic hearts, thereby reducing cardiac injury and dysfunction .
Recombinant human Osteocrin is produced using human embryonic kidney (HEK) cells. This method ensures high purity and biological activity of the protein, making it suitable for various research applications. Recombinant Osteocrin is used to study its effects on bone growth, muscle function, and cardiovascular health in vitro and in vivo .
