OSCAR Human, Sf9

The Osteoclast Associated, Immunoglobulin-Like Receptor (OSCAR) is a protein encoded by the OSCAR gene. This receptor is a member of the leukocyte receptor complex protein family and plays a crucial role in the regulation of both innate and adaptive immune responses . OSCAR is specifically expressed in preosteoclasts and mature osteoclasts, making it an important regulator of osteoclast differentiation .

OSCAR is an IgG-like receptor that acts as a costimulatory receptor for osteoclast differentiation through the activation of NFATc1 . Osteoclasts are multinucleated cells responsible for bone resorption, a process essential for bone homeostasis . The receptor’s expression is highly conserved across different species, highlighting its significance in bone biology .

OSCAR has been identified as a key mediator in osteoimmunology, the study of the interface between the skeletal and immune systems . It plays a role in oxidative stress-mediated atherogenesis and monocyte adhesion . The receptor’s involvement in these processes underscores its importance in both bone health and immune regulation.

The human recombinant form of OSCAR, produced in Sf9 insect cells, is used in various research applications. This recombinant protein allows scientists to study the receptor’s function and its role in osteoclastogenesis and immune responses in a controlled environment.

Mutations or dysregulation of the OSCAR gene have been associated with various diseases, including malignant leptomeningeal neoplasm and leptomeninges sarcoma . Understanding the function and regulation of OSCAR can provide insights into potential therapeutic targets for these conditions.