Ornipressin
Greater than 97.0% as determined by analysis by RP-HPLC.
Description
Ornipressin Synthetic is a single, non-glycosylated polypeptide chain containing 9 amino acids, having a molecular mass of 1042.19 Dalton and a Molecular formula of C45H63N13O12 S2.
Product Specs
H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Orn-Gly-NH2.
Product Science Overview
Ornipressin has a complex chemical structure, with the IUPAC name (2S)-N-[(2S)-5-Amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide . It has a molecular formula of C45H63N13O12S2 and a molar mass of 1042.19 g/mol .
Ornipressin is primarily used as a vasoconstrictor and haemostatic agent. It is effective in controlling bleeding during surgeries and in treating conditions like esophageal varices, where blood vessels in the esophagus become enlarged and prone to bleeding . Additionally, it has been used in the management of adrenaline-resistant anaphylaxis, a severe allergic reaction that does not respond to standard adrenaline treatment .
Ornipressin works by binding to vasopressin receptors in the blood vessels, causing them to constrict. This vasoconstriction helps to increase blood pressure and reduce blood flow to certain areas, which is particularly useful in controlling bleeding . It also has antidiuretic properties, meaning it can reduce urine production by increasing water reabsorption in the kidneys .
- Surgical Procedures: Ornipressin is often used during surgeries to control bleeding and maintain stable blood pressure. Its vasoconstrictive properties make it an effective agent in reducing blood loss.
- Anaphylaxis Management: In cases of adrenaline-resistant anaphylaxis, ornipressin has been shown to be effective in restoring blood pressure and heart rate when standard treatments fail .
- Esophageal Varices: Ornipressin is used to manage bleeding from esophageal varices, which are dilated blood vessels in the esophagus that can rupture and cause significant bleeding .
While ornipressin is generally effective, it can have side effects, including hypertension (high blood pressure), bradycardia (slow heart rate), and potential allergic reactions. It is important for healthcare providers to monitor patients closely when administering this medication to manage any adverse effects promptly .
