Omp Pylori
Description
Product Specs
KDFTFVCPTEIIAFDKRVKDFQEKGFNVIGVSIDSEQVHFAWK
NTPVEKGGIGQVTFPMVADITKSISRDYDVLFEEAIALRGAFLI
DKNMKVRHAVINDLPLGRNADEMLRMVDALLHFEEHGEVCP
AGWRKGDKGMKATHQGVAEYLKENSIKL.
Product Science Overview
Helicobacter pylori is a Gram-negative, microaerophilic bacterium that primarily colonizes the human stomach. It is known for its helical shape and high motility, which is facilitated by its flagella. This bacterium is a significant human pathogen, infecting over half of the world’s population. While many infections are asymptomatic, H. pylori is a recognized risk factor for various gastric disorders, including gastritis, peptic ulcers, and gastric cancer .
The outer membrane of H. pylori is a critical component of its structure and function. It consists of two highly asymmetric layers: the inner monolayer contains phospholipids, while the outer monolayer is composed mainly of outer membrane proteins (OMPs). These OMPs play a crucial role in the bacterium’s ability to adapt to the gastric environment and facilitate infection .
H. pylori’s pathogenicity is largely attributed to its virulence factors, including CagA and VacA, as well as its OMPs. These proteins help the bacterium adhere to gastric epithelial cells, colonize the stomach, and evade the host immune response. Some of the well-studied OMPs include BabA (HopS), SabA (HopP), OipA (HopH), HopQ, and HopZ .
Recombinant outer membrane proteins of H. pylori are produced using genetic engineering techniques. These proteins are expressed in a host organism, such as Escherichia coli, and then purified for use in research and potential therapeutic applications. The recombinant proteins are used to study the structure, function, and immunogenicity of H. pylori OMPs. They are also being investigated as potential targets for novel therapies and vaccines .
Understanding the role of H. pylori OMPs in the bacterium’s pathogenicity is essential for developing new strategies to combat H. pylori-related diseases. Research on recombinant OMPs has provided valuable insights into the mechanisms of H. pylori infection and its interactions with the host. These studies have also highlighted the potential of OMPs as targets for therapeutic interventions and vaccine development .
