OCIAD2 Human

OCIAD2 consists of seven exons and is expressed in multiple tissues, including the kidney, liver, and brain. The protein encoded by OCIAD2 is approximately 152 amino acids in length and shares significant amino acid identity with its paralog, OCIAD1 . The expression of OCIAD2 is regulated at both the transcriptional and post-transcriptional levels, with various splice variants observed in different tissues .

OCIAD2 is involved in several critical cellular processes, including endocytosis, hematopoietic stem cell homeostasis, and the positive regulation of receptor signaling pathways via the JAK-STAT pathway . The protein is predicted to be located in the Golgi apparatus, endosomes, and lysosomes, indicating its role in intracellular trafficking and signaling .

OCIAD2 facilitates the activation of STAT3, a transcription factor involved in various cellular responses, including cell growth and apoptosis . The OCIA domain of OCIAD2 contains a double helical motif that is essential for its interaction with STAT3 and its subcellular localization . Overexpression of OCIAD2 enhances STAT3 activation, while knockdown of OCIAD2 reduces STAT3 activation and cell migration .

Mutations or dysregulation of OCIAD2 have been associated with certain diseases, including biliary dyskinesia . The protein’s role in regulating critical signaling pathways makes it a potential target for therapeutic interventions in diseases where these pathways are dysregulated.

Research on OCIAD2 has primarily focused on its role in cellular signaling and its potential as a therapeutic target. Studies have utilized various techniques, including immunoprecipitation, Western blot analysis, and immunofluorescence, to elucidate the function and localization of OCIAD2 . The recombinant form of OCIAD2 is used in research to study its interactions and functions in vitro.