NUDT1 Antibody
Description
Product Specs
Product Science Overview
NUDT1 is responsible for hydrolyzing oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, into their corresponding monophosphates . This hydrolysis prevents the incorporation of these oxidized nucleotides into DNA and RNA, which could otherwise lead to mutations and genomic instability. By sanitizing the nucleotide pool, NUDT1 helps prevent A:T to C:G transversions and other mutagenic events .
NUDT1 is primarily localized in the cytoplasm, but it is also found in the mitochondria . This dual localization suggests that NUDT1 is involved in the sanitization of nucleotide pools for both nuclear and mitochondrial genomes. The expression of NUDT1 varies across different tissues, with higher expression levels observed in testis, thymus, and certain cell lines such as Jurkat and HeLa cells .
Mutations or dysregulation of NUDT1 have been associated with various diseases, including familial adenomatous polyposis and Parkinson’s disease . The enzyme’s role in preventing oxidative DNA damage makes it a potential target for therapeutic interventions aimed at reducing mutagenesis and tumorigenesis.
Mouse anti-human NUDT1 antibodies are monoclonal antibodies specifically designed to target and bind to the human NUDT1 protein. These antibodies are used in various research applications, including Western blotting, immunohistochemistry, and ELISA, to study the expression and function of NUDT1 in different biological contexts .
