Nucleosome Bovine
Bovine tissues.
Greater than 95.0% as determined by SDS-PAGE.
Description
Nucleosome Bovine shows multiple bands between 14-18kDa and is purified from bovine tissues by proprietary protein-chemical techniques.
Product Specs
Bovine tissues.
Product Science Overview
The nucleosome is the fundamental unit of chromatin, which is the complex of DNA and proteins found in the nucleus of eukaryotic cells. It plays a crucial role in the regulation of gene expression and DNA replication. The nucleosome consists of an octamer of core histones (H2A, H2B, H3, and H4) around which approximately 147 base pairs of DNA are wrapped. Additionally, linker DNA connects adjacent nucleosomes, and the linker histone H1 binds to this region, further stabilizing the structure .
In bovine cells, as in other eukaryotes, the nucleosome is composed of core histones and linker histones. The core histones form the nucleosome core particle, while the linker histone H1 binds to the DNA between nucleosomes, aiding in the compaction of chromatin. The core histones are highly conserved proteins that play a key role in the structural organization of chromatin .
The primary function of the nucleosome is to package DNA into a more compact, dense shape, which allows for efficient storage of genetic information within the cell nucleus. This packaging also plays a critical role in regulating gene expression, as the accessibility of DNA to transcription factors and other regulatory proteins is influenced by the nucleosome structure .
In bovine cells, the regulation of nucleosome structure and function is essential for various biological processes, including cell division, differentiation, and development. For instance, the linker histone H1FOO has been shown to be crucial for bovine preimplantation development by regulating chromatin structure and lineage specification .
Recent studies have highlighted the importance of nucleosome dynamics in bovine oocyte growth and preimplantation development. Single-cell RNA sequencing has revealed transcriptome dynamics during bovine oocyte growth, providing insights into the key genes and pathways involved in this process . Additionally, comprehensive transcriptome analyses of bovine preimplantation embryos have identified thousands of genes expressed during early development, underscoring the complexity and significance of nucleosome regulation in bovine biology .
