NRIP3 Human

The NRIP3 gene encodes a protein that is involved in the interaction with nuclear receptors. These receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. The interaction between NRIP3 and these receptors is essential for the regulation of gene expression .

NRIP3 is predicted to enable aspartic-type endopeptidase activity, which means it is involved in the breakdown of proteins by cleaving peptide bonds. This activity is crucial for various cellular processes, including protein degradation and processing . The protein is predominantly localized in the cytoplasm but can shuttle between the nucleus and cytoplasm, depending on specific signals .

Mutations or dysregulation of the NRIP3 gene have been associated with several diseases, including Familial Behcet-Like Autoinflammatory Syndrome and Cone-Rod Dystrophy 20 . These conditions highlight the importance of NRIP3 in maintaining normal cellular functions and its potential role in disease pathogenesis.

Human recombinant NRIP3 is used in various research applications to study its function and role in disease. Recombinant proteins are proteins that are artificially made through the expression of recombinant DNA within living cells. These proteins are crucial for understanding the molecular mechanisms of diseases and for developing potential therapeutic interventions.