NREP Human
Neuronal Regeneration Related Protein Human Recombinant
Cat. No.
BT1115
Source
Escherichia Coli.
Synonyms
Neuronal regeneration-related protein, Neuronal protein 3.1, Protein p311, NREP, C5orf13, P311, PTZ17, Chromosome 5 Open Reading Frame 13, Neuronal Regeneration Related Protein Homolog (Rat), D4S114, PRO1873, SEZ17, Neuronal Regeneration Related Protein Homolog, Neuronal Regeneration-Related Protein.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
NREP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 91 amino acids (1-68) and having a molecular mass of 10.3kDa.
NREP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
NREP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Neuronal Regeneration Related Protein (NREP) is involved in neural function, specifically in promoting axonal regeneration. It also plays a role in cellular differentiation, including inducing fibroblast differentiation into myofibroblasts and enhancing retinoic-acid regulation of lipid-droplet biogenesis. NREP downregulates the expression of transforming growth factor beta 1 (TGFB1) and TGFB2, but not TGFB3. Additionally, it contributes to the regulation of alveolar generation.
Description
Recombinant human NREP, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 91 amino acids (residues 1-68) with a molecular weight of 10.3 kDa. It includes a 23 amino acid His-tag fused to the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A sterile, filtered solution that is colorless.
Formulation
The NREP solution is provided at a concentration of 0.5 mg/ml in a buffer consisting of 20 mM Tris-HCl (pH 8.0), 10% glycerol, and 0.1 M NaCl.
Stability
For short-term storage (2-4 weeks), keep refrigerated at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Minimize repeated freeze-thaw cycles.
Purity
Purity is determined to be greater than 85.0% using SDS-PAGE analysis.
Synonyms
Neuronal regeneration-related protein, Neuronal protein 3.1, Protein p311, NREP, C5orf13, P311, PTZ17, Chromosome 5 Open Reading Frame 13, Neuronal Regeneration Related Protein Homolog (Rat), D4S114, PRO1873, SEZ17, Neuronal Regeneration Related Protein Homolog, Neuronal Regeneration-Related Protein.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMVYYPEL FVWVSQEPFP NKDMEGRLPK GRLPVPKEVN RKKNDETNAA SLTPLGSSEL RSPRISYLHF F.
Product Science Overview
Biological Functions and Mechanisms
NREP is involved in several critical biological processes, including:
- Axon Regeneration: NREP is predicted to be involved in the regeneration of axons, which are essential for the transmission of nerve impulses .
- Neuron Differentiation: It plays a role in the differentiation of neurons, helping to form specialized nerve cells from precursor cells .
- Transforming Growth Factor Beta (TGF-β) Signaling Pathway: NREP is involved in the regulation of the TGF-β signaling pathway, which is crucial for cell growth, proliferation, differentiation, and apoptosis .
Cellular Localization
Clinical Significance
NREP has been identified as a diagnostic and prognostic biomarker for certain cancers, such as gastric cancer. Its expression levels are typically upregulated in gastric cancer tissues compared to normal tissues . The protein promotes gastric cancer cell proliferation and angiogenesis, making it a potential target for therapeutic interventions .
Research and Therapeutic Potential
Given its role in neural function and regeneration, NREP is a promising candidate for research into neurodegenerative diseases and neural injuries. Its ability to promote axonal regeneration and influence neuron differentiation makes it a potential therapeutic target for conditions such as spinal cord injuries and neurodegenerative disorders.
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