NKp44 Antibody

Natural Killer (NK) cells are a type of lymphocyte critical to the innate immune system. They play a significant role in the body’s defense against tumors and virally infected cells. One of the key receptors on NK cells is the NKp44 receptor, also known as Natural Killer Cell p44-Related Protein or CD336. This receptor is involved in the activation and regulation of NK cell functions.

NKp44 is a transmembrane glycoprotein characterized by a single extracellular V-type Ig-like domain and a cytoplasmic tail containing an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) but no known activating signaling motifs . It is encoded by the NCR2 gene and is expressed on activated NK cells. The receptor is involved in recognizing and binding to specific ligands on target cells, leading to the activation of NK cell cytotoxicity and cytokine production.

The Mouse Anti-Human NKp44 antibody is a monoclonal antibody developed to specifically detect human NKp44. This antibody is used in various research applications, including flow cytometry, immunohistochemistry, and functional assays . It is produced by immunizing mice with human NKp44 protein and then isolating the specific antibody-producing hybridoma cells.

The Mouse Anti-Human NKp44 antibody is widely used in research to study NK cell biology and the role of NKp44 in immune responses. It has been shown to induce IFN-gamma secretion in human NK cells activated with recombinant human IL-2 in a dose-dependent manner . This makes it a valuable tool for investigating the mechanisms of NK cell activation and the potential therapeutic applications of targeting NKp44 in cancer and infectious diseases.