NIPSNAP1 Human
Nipsnap Homolog 1 Human Recombinant
Cat. No.
BT29495
Source
Escherichia Coli.
Synonyms
Nipsnap Homolog 1 (C. Elegans), 4 Nitrophenylphosphatase Domain And Non-Neuronal SNAP25-Like 1, NIPSNAP, C. Elegans, Homolog, Protein NipSnap Homolog 1, NipSnap1.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
NIPSNAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (1-284a.a) and having a molecular mass of 35.7kDa.
NIPSNAP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
NIPSNAP1 (Nipsnap Homolog 1) is part of the NipSnap family and may be involved in vesicular transport. In mice, a similar protein inhibits the TRPV6 calcium channel and is found in the inner mitochondrial membrane, potentially playing a role in mitochondrial DNA maintenance. NIPSNAP1 has a pseudogene located on chromosome 17's short arm and is associated with diseases like maple syrup urine disease and phenylketonuria.
Description
Recombinant NIPSNAP1, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 307 amino acids (1-284a.a) with a molecular weight of 35.7kDa. It includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The NIPSNAP1 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea, and 10% glycerol.
Stability
For best results, store at 4°C and use within 2-4 weeks. For long-term storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for extended storage. Avoid repeated freeze-thaw cycles.
Purity
SDS-PAGE analysis indicates a purity greater than 85%.
Synonyms
Nipsnap Homolog 1 (C. Elegans), 4 Nitrophenylphosphatase Domain And Non-Neuronal SNAP25-Like 1, NIPSNAP, C. Elegans, Homolog, Protein NipSnap Homolog 1, NipSnap1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAPRLCS ISVTARRLLG GPGPRAGDVA SAAAARFYSK DNEGSWFRSL FVHKVDPRKD AHSTLLSKKE TSNLYKIQFH NVKPEYLDAY NSLTEAVLPK LHLDEDYPCS LVGNWNTWYG EQDQAVHLWR FSGGYPALMD CMNKLKNNKE YLEFRRERSQ
MLLSRRNQLL LEFSFWNEPQ PRMGPNIYEL RTYKLKPGTM IEWGNNWARA IKYRQENQEA VGGFFSQIGE LYVVHHLWAY KDLQSREETR NAAWRKRGWD ENVYYTVPLV RHMESRIMIP LKISPLQ
Product Science Overview
Gene and Protein Structure
The NIPSNAP1 gene is located on chromosome 22 and encodes a protein that consists of 284 amino acids . The protein has a molecular weight of approximately 35.7 kDa . The recombinant form of NIPSNAP1 is often produced in Escherichia coli (E. coli) and includes an N-terminal His-tag for purification purposes .
Function and Localization
NIPSNAP1 is primarily localized to the inner mitochondrial membrane, where it may play a role in mitochondrial DNA maintenance . In mice, a similar protein has been shown to inhibit the calcium channel TRPV6 . This suggests that NIPSNAP1 may have a regulatory role in calcium signaling and homeostasis.
Biological Significance
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
