NFKBIB Human
Description
NFKBIB is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
APDTYLAQGP DRTPDTNHTP VALYPDSDLE KEEEESEEDW KLQLEAENYE GHTPLHVAVI HKDVEMVRLL RDAGADLDKP EPTCGRSPLH LAVEAQAADV LELLLRAGAN PAARMYGGRT PLGSAMLRPN PILARLLRAH GAPEPEGEDE KSGPCSSSSD SDSGDEGDEY DDIVVHSSRS QTRLPPTPAS KPLPDDPRPV.
Product Science Overview
NF-kappa-B (NF-κB) is a crucial nuclear transcription factor that regulates the expression of various genes involved in immune and inflammatory responses, cell proliferation, and survival . The activity of NF-κB is tightly controlled by a family of inhibitory proteins known as Inhibitor kappa B (IκB) proteins . Among these, NF-kappa-B Inhibitor Beta (NFKBIB) plays a significant role in modulating the NF-κB pathway .
The NF-κB pathway is activated in response to various stimuli, including cytokines, stress, free radicals, and bacterial or viral antigens . In its inactive state, NF-κB is sequestered in the cytoplasm by IκB proteins . Upon activation, IκB proteins are phosphorylated by IκB kinase (IKK) complex, leading to their ubiquitination and subsequent degradation . This degradation releases NF-κB, allowing it to translocate to the nucleus and initiate the transcription of target genes .
NFKBIB, also known as IκBβ, is one of the key inhibitory proteins that regulate the NF-κB pathway . It binds to NF-κB dimers, preventing their nuclear translocation and subsequent gene transcription . The degradation of NFKBIB is a critical step in the activation of NF-κB, making it a potential target for therapeutic interventions in diseases characterized by excessive NF-κB activity .
Human recombinant NFKBIB is a laboratory-produced version of the natural protein. It is synthesized using recombinant DNA technology, which involves inserting the gene encoding NFKBIB into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities . This recombinant protein can be used in various research and therapeutic applications to study the NF-κB pathway and develop potential treatments for diseases involving NF-κB dysregulation .
The NF-κB pathway is implicated in numerous diseases, including cancer, autoimmune disorders, and inflammatory conditions . By inhibiting the degradation of NFKBIB, it is possible to prevent the activation of NF-κB and reduce the expression of pro-inflammatory and pro-survival genes . This makes NFKBIB a promising target for drug development aimed at treating conditions associated with chronic inflammation and abnormal cell proliferation .
