NFATC1 Antibody
Sterile filtered colorless solution.
Description
Product Specs
Product Science Overview
Nuclear Factor of Activated T-Cells Cytoplasmic 1 (NFATC1) is a protein encoded by the NFATC1 gene in humans. This protein is a crucial component of the nuclear factor of activated T cells (NFAT) DNA-binding transcription complex, which plays a significant role in the immune response by regulating the expression of various cytokine genes .
NFATC1 is involved in the inducible expression of cytokine genes in T-cells, particularly in the transcription of IL-2 and IL-4 genes . The NFAT transcription complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component . This translocation is dependent on the calcium/calmodulin-dependent phosphatase calcineurin, which dephosphorylates NFAT proteins, allowing them to enter the nucleus and initiate transcription .
NFATC1 is a major molecular target for immunosuppressive drugs such as cyclosporin A, which inhibit calcineurin and thus prevent NFATC1 from translocating to the nucleus . This inhibition is crucial in preventing the activation and proliferation of T-cells, which is beneficial in conditions requiring immunosuppression, such as organ transplantation and autoimmune diseases .
Mouse anti-human antibodies are secondary antibodies generated by immunizing mice with human immunoglobulins. These antibodies are affinity-purified and have well-characterized specificity for human immunoglobulins . They are widely used in various immunological assays, including ELISA, Western Blot, Flow Cytometry, and Immunohistochemistry . These secondary antibodies offer increased versatility and sensitivity through signal amplification, as multiple secondary antibodies can bind to a single primary antibody .
Mouse anti-human antibodies are essential tools in biomedical research for detecting, sorting, or purifying human proteins. They are used in various experimental setups to study protein expression, localization, and interactions . The development of these antibodies has significantly advanced our understanding of human immunology and has facilitated numerous discoveries in the field.
