NEFH Bovine

Neurofilaments are a type of intermediate filament found in neurons, playing a crucial role in maintaining the structural integrity and function of nerve cells. They are composed of three main subunits: the light chain (NfL), medium chain (NfM), and heavy chain (NfH). The neurofilament heavy chain (NfH) is the largest of these subunits and is essential for the proper functioning of the nervous system.

Neurofilament heavy chains are characterized by their high molecular weight and extensive phosphorylation. They are integral to the cytoskeleton of neurons, providing structural support and aiding in the transport of organelles and other cellular components along axons . The phosphorylation of NfH is particularly important as it influences the spacing between neurofilaments, thereby affecting the overall stability and elasticity of the axonal cytoskeleton .

Neurofilament heavy chains have gained significant attention as potential biomarkers for neurodegenerative diseases. Elevated levels of NfH in cerebrospinal fluid and blood have been associated with conditions such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Alzheimer’s disease . The release of NfH into biofluids is indicative of axonal damage and neuronal degeneration, making it a valuable tool for diagnosing and monitoring the progression of these diseases .

The study of neurofilament heavy chains in bovine models has provided valuable insights into their function and role in neurodegeneration. Bovine neurofilament heavy chains share a high degree of similarity with their human counterparts, making them a useful model for studying the molecular mechanisms underlying neurodegenerative diseases . Research on bovine NfH has contributed to the development of diagnostic assays and therapeutic strategies aimed at mitigating neuronal damage and promoting neuroprotection .