NDUFS3 Human
Description
Product Specs
Product Science Overview
NDUFS3 is a subunit of the NADH:ubiquinone oxidoreductase complex (Complex I) in the mitochondria. It is involved in the transfer of electrons from NADH to ubiquinone, a key step in the mitochondrial electron transport chain. This process is vital for the generation of a proton gradient across the mitochondrial membrane, which drives ATP synthesis through oxidative phosphorylation.
The recombinant form of this protein is produced in E. coli and is typically non-glycosylated. It is a single polypeptide chain that contains histidine residues, which facilitate its purification and study in laboratory settings .
The study of NDUFS3 is essential for understanding mitochondrial function and its role in various diseases. Mutations or deficiencies in this protein can lead to mitochondrial dysfunction, which is associated with a range of disorders, including neurodegenerative diseases, metabolic syndromes, and aging-related conditions.
Recombinant NDUFS3 is widely used in research to investigate the mechanisms of mitochondrial diseases and to develop potential therapeutic interventions. By studying the recombinant form, scientists can gain insights into the protein’s structure, function, and interactions with other components of the electron transport chain.
- Disease Research: Understanding the role of NDUFS3 in mitochondrial diseases.
- Drug Development: Screening potential drugs that target mitochondrial dysfunction.
- Biochemical Studies: Investigating the electron transport chain and ATP synthesis.
