NCR3 antibody

Natural Cytotoxicity Triggering Receptor 3 (NCR3), also known as NKp30 or CD337, is a protein-coding gene that plays a crucial role in the immune system, particularly in the function of natural killer (NK) cells. These receptors are involved in the recognition and destruction of tumor cells and virus-infected cells .

NCR3 is a cell membrane receptor found on NK cells. It is activated by binding to extracellular ligands such as BAG6 and NCR3LG1. This interaction stimulates NK cell cytotoxicity towards neighboring cells that produce these ligands, including tumor cells . Additionally, NCR3 engagement promotes the maturation of myeloid dendritic cells (DCs) by inducing the release of TNFA and IFNG from NK cells, which further enhances DC maturation .

The NCR3 gene is located on chromosome 6 and has several aliases, including NKp30, CD337, and LY117 . It has three transcript variants encoding different isoforms. A single nucleotide polymorphism in the 5’ untranslated region of this gene has been associated with mild malaria susceptibility .

NCR3 is involved in the innate immune system and plays a significant role in the body’s defense against tumors and viral infections. It is part of the Class I MHC-mediated antigen processing and presentation pathway . Diseases associated with NCR3 include mild malaria and other conditions related to immune system dysfunction .

The understanding of NCR3’s role in immune responses has led to its exploration as a potential therapeutic target. By harnessing NCR3 biology, novel therapeutic interventions are being developed to enhance tumor surveillance and improve immune responses against various diseases .

Mouse anti-human NCR3 antibodies are used in research to study the function and regulation of NCR3 in human cells. These antibodies help in identifying and isolating NK cells expressing NCR3, facilitating the study of their role in immune responses and disease mechanisms .