NCR2 Human
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Description
Product Specs
Product Science Overview
Natural Cytotoxicity Triggering Receptor 2 (NCR2), also known as NKp44 or CD336, is a protein encoded by the NCR2 gene in humans. This receptor is a crucial component of the immune system, particularly in the function of natural killer (NK) cells, which play a vital role in the body’s defense against tumors and virally infected cells .
NCR2 is a transmembrane protein that belongs to the family of natural cytotoxicity receptors (NCRs), which also includes NKp30 (NCR3) and NKp46 (NCR1). These receptors are essential for the activation and regulation of NK cell cytotoxicity. NKp44 is unique among the NCRs as it is expressed exclusively on activated NK cells .
The primary function of NCR2 is to enhance the cytotoxic activity of NK cells. It achieves this by recognizing and binding to specific ligands on the surface of target cells, leading to the activation of NK cells and subsequent lysis of the target cells. This process is critical for the immune system’s ability to eliminate cancerous and infected cells .
NCR2 interacts with various ligands, including membrane-associated heparan sulfate glycosaminoglycans, viral hemagglutinin, and β-1,3-glucan. These interactions are pivotal for the receptor’s ability to recognize and bind to target cells. The binding of NCR2 to its ligands triggers a cascade of intracellular signaling events that result in the activation of NK cells .
The role of NCR2 in mediating NK cell cytotoxicity has significant implications for cancer immunotherapy. By enhancing the activity of NK cells, NCR2 can potentially improve the immune system’s ability to target and destroy tumor cells. Additionally, the receptor’s involvement in the immune response to viral infections highlights its importance in antiviral immunity .
Research on NCR2 has focused on understanding its structure, function, and interactions with ligands. Studies have also explored the potential of targeting NCR2 in cancer therapy, aiming to boost the immune system’s ability to fight cancer. The development of human recombinant NCR2 has facilitated these studies by providing a consistent and reliable source of the protein for experimental purposes .
