N-Acetyltransferase 6 (NAT6), also known as FUS-2 or Protein fus-2, is an enzyme that belongs to the GCN5-related N-acetyltransferase (GNAT) family. This enzyme is involved in the acetylation of proteins, a crucial post-translational modification that can affect protein function, stability, and interactions. The mouse anti-human NAT6 antibody is a polyclonal antibody raised in mice against the full-length human NAT6 protein.
NAT6 is encoded by the NAT6 gene, which is located on chromosome 3 in humans. The enzyme consists of 308 amino acids and has a molecular weight of approximately 34 kDa. NAT6 is known to acetylate the N-terminal residues of various proteins, which can influence their activity and interactions. This modification is essential for regulating protein function and maintaining cellular homeostasis.
The acetylation activity of NAT6 plays a significant role in various cellular processes, including gene expression, protein stability, and signal transduction. By modifying the N-terminal residues of target proteins, NAT6 can alter their function and interactions, thereby influencing cellular pathways and responses. Dysregulation of NAT6 activity has been implicated in various diseases, including cancer, where abnormal protein acetylation can contribute to tumorigenesis and progression.
The mouse anti-human NAT6 antibody is a polyclonal antibody produced by immunizing mice with the full-length human NAT6 protein. This antibody is used in various research applications, including Western blotting, immunoprecipitation, and immunofluorescence, to detect and study the expression and function of NAT6 in human samples. The antibody is available from various suppliers, such as Abnova Corporation and Aviva Systems Biology .
Researchers use the mouse anti-human NAT6 antibody to investigate the role of NAT6 in different biological processes and diseases. By studying the expression and function of NAT6, scientists can gain insights into its involvement in cellular pathways and its potential as a therapeutic target. The antibody is also used to explore the mechanisms underlying protein acetylation and its impact on cellular function.