NAA10 Human
N-alpha-acetyltransferase 10, N-terminal acetyltransferase complex ARD1 subunit homolog A, NatA catalytic subunit, NAA10, ARD1, ARD1A, TE2, NATD, DXS707.
Description
NAA10 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 255 amino acids (1-235 a.a.) and having a molecular mass of 28.6kDa (the molecular weight on SDS-PAGE will appear higher).
NAA10 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
N-alpha-acetyltransferase 10, N-terminal acetyltransferase complex ARD1 subunit homolog A, NatA catalytic subunit, NAA10, ARD1, ARD1A, TE2, NATD, DXS707.
MGSSHHHHHH SSGLVPRGSH MNIRNARPED LMNMQHCNLL CLPENYQMKY YFYHGLSWPQ LSYIAEDENG KIVGYVLAKM EEDPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE NFNAKYVSLH VRKSNRAALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD LTQMADELRR HLELKEKGRH VVLGAIENKV ESKGNSPPSS GEACREEKGL AAEDSGGDSK DLSEVSETTE STDVKDSSEA SDSAS.
Product Science Overview
The NAA10 gene is located on the X chromosome at position Xq28 and consists of eight exons . The gene encodes multiple isoforms through alternative splicing, which results in different protein variants . The primary function of the NAA10 protein is to catalyze the transfer of an acetyl group from acetyl-CoA to the N-terminal amino group of nascent polypeptides .
NAA10, in conjunction with its auxiliary subunit NAA15, forms the NatA complex. This complex is responsible for the N-terminal acetylation of proteins, a modification that occurs co-translationally as the polypeptide emerges from the ribosome . N-terminal acetylation is one of the most common protein modifications in eukaryotic cells and is essential for normal cell function .
The NatA complex specifically acetylates proteins that have a small, uncharged N-terminal residue following the initiator methionine, which is often cleaved off . This modification can affect protein stability, localization, and interactions, thereby influencing various cellular processes .
NAA10 is involved in several critical biological processes, including:
- Protein Acetylation: Modifying the N-terminal amino acids of proteins, which can impact their function and stability .
- Cell Cycle Regulation: NAA10 has been implicated in the regulation of the cell cycle and maintenance of mitotic sister chromatid cohesion .
- Development: The enzyme plays a role in embryonic development and cellular differentiation .
Recombinant human NAA10 is used in research to study its function and role in various biological processes. Understanding the mechanisms of NAA10 and its interactions with other proteins can provide insights into the development of therapeutic strategies for diseases associated with its dysfunction .
