MZB1 Human

Marginal Zone B And B1 Cell-Specific Protein Human Recombinant
Cat. No.
BT27301
Source
Escherichia Coli.
Synonyms
Marginal Zone B and B1 Cell-Specific Protein, MZB1, PACAP, Mesenteric Oestrogen-Dependent Adipose Gene- 7, Plasma Cell-Induced ER Protein 1, Proapoptotic Caspase Adaptor Protein, Mesenteric Estrogen-Dependent Adipose 7, Plasma Cell-Induced Resident Endoplasmic Reticulum Protein, Plasma Cell-Induced Resident ER Protein, Proapoptotic Caspase Adapter Protein, MEDA-7, pERp1, HSPC190, Caspase-2 Binding Protein, Marginal Zone B- And B1-Cell-Specific Protein, MEDA7, MGC29506.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

MZB1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (1-97) and having a molecular mass of 12.9 kDa.
MZB1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Marginal zone B- and B1-cell-specific protein (MZB1) is a hormone-regulated adipokine and proinflammatory cytokine involved in chronic inflammation and cellular expansion. It plays a role in linking immunoglobulin M (IgM) heavy and light chains, thereby stimulating IgM assembly and secretion. MZB1's functions are attributed to its role as a molecular chaperone and its low level of oxidoreductase activity. Additionally, MZB1 contributes to the diversity of peripheral B-cell functions by regulating calcium ion (Ca2+) stores, antibody secretion, and integrin activation.
Description
Recombinant human MZB1, expressed in E.coli, is a single, non-glycosylated polypeptide chain comprising 120 amino acids (residues 1-97) with a molecular weight of 12.9 kDa. This protein includes a 23-amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless solution, sterile-filtered.
Formulation
The MZB1 solution (0.5 mg/mL) is supplied in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 10% glycerol, and 1 mM DTT.
Stability
The product can be stored at 4°C for 2-4 weeks if used within that period. For extended storage, freeze at -20°C. To ensure long-term stability, adding a carrier protein (0.1% HSA or BSA) is recommended. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 90.0% as determined by SDS-PAGE analysis.
Synonyms
Marginal Zone B and B1 Cell-Specific Protein, MZB1, PACAP, Mesenteric Oestrogen-Dependent Adipose Gene- 7, Plasma Cell-Induced ER Protein 1, Proapoptotic Caspase Adaptor Protein, Mesenteric Estrogen-Dependent Adipose 7, Plasma Cell-Induced Resident Endoplasmic Reticulum Protein, Plasma Cell-Induced Resident ER Protein, Proapoptotic Caspase Adapter Protein, MEDA-7, pERp1, HSPC190, Caspase-2 Binding Protein, Marginal Zone B- And B1-Cell-Specific Protein, MEDA7, MGC29506.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPAELWL TSYGVREVDQ VKRLTGPGLS EGPEPSISVM VTGGPWPTRL SRTCLHYLGE FGEDQIYEAH QQGRGALEAL LCGGPQGACS EKVSATREEL.

Product Science Overview

Introduction

Marginal Zone B and B1 Cell-Specific Protein, also known as MZB1, is a protein encoded by the MZB1 gene in humans. This protein plays a crucial role in the immune system, particularly in the function and regulation of B cells, which are a type of white blood cell essential for the adaptive immune response .

Gene and Protein Structure

The MZB1 gene is located on chromosome 5 and is responsible for encoding the MZB1 protein. This protein is also known by several aliases, including HSPC190, MEDA-7, PACAP, and pERp1 . The MZB1 protein is involved in various cellular processes, including the regulation of calcium stores, antibody secretion, and integrin activation .

Function and Mechanism

MZB1 associates with immunoglobulin M (IgM) heavy and light chains, promoting their assembly and secretion. It may function as a molecular chaperone or an oxidoreductase, displaying a low level of oxidoreductase activity . Additionally, MZB1 helps diversify peripheral B-cell functions by regulating calcium stores, antibody secretion, and integrin activation .

Role in Diseases

MZB1 has been implicated in several diseases, including late-onset retinal degeneration and non-syndromic X-linked intellectual disability 30 . It acts as a hormone-regulated adipokine/pro-inflammatory cytokine, contributing to chronic inflammation, cellular expansion, and insulin resistance in adipocytes . This protein’s role in inflammation and insulin resistance suggests its potential involvement in metabolic disorders .

Expression and Localization

MZB1 is expressed in various tissues, including lymphoid tissue, bone marrow, testis, and skeletal muscle . It is primarily located in the cytoplasm and extracellular region . The protein’s expression and localization are crucial for its function in immune response and cellular regulation .

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