MYOZ1 Human
Myozenin 1 Human Recombinant
Cat. No.
BT27246
Source
Escherichia Coli.
Synonyms
CS-2, FATZ, MYOZ, Calsarcin-2, Filamin-, actinin- and telethonin-binding protein,Protein FATZ, MYOZ1.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
MYOZ1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 322 amino acids (1-299 a.a.) and having a molecular mass of 34.1kDa.
MYOZ1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MYOZ1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Myozenin 1 (MYOZ1) is a protein that is part of the myozenin family. It is primarily found in skeletal muscle. Myozenin family members interact with a protein called calcineurin, attaching it to the sarcomere, a structural unit of muscle cells. This interaction is important for regulating calcineurin's signaling activity in heart and skeletal muscle.
Description
This product contains a recombinant human MYOZ1 protein. It is produced in E. coli bacteria and consists of a single polypeptide chain of 322 amino acids (specifically, amino acids 1 to 299 of the MYOZ1 protein), with an additional 23-amino acid His-tag attached to the N-terminus. This protein is not glycosylated and has a molecular weight of 34.1 kDa. The MYOZ1 protein was purified using specialized chromatography techniques.
Physical Appearance
A clear solution that has been sterilized by filtration.
Formulation
This MYOZ1 protein solution has a concentration of 1 mg/ml and is prepared in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.4 M urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep refrigerated at 4°C. For long-term storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for extended storage. Avoid repeatedly freezing and thawing the product.
Purity
The purity of this product is greater than 90%, as determined by SDS-PAGE analysis.
Synonyms
CS-2, FATZ, MYOZ, Calsarcin-2, Filamin-, actinin- and telethonin-binding protein,Protein FATZ, MYOZ1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPLSGTP APNKKRKSSK LIMELTGGGQ ESSGLNLGKK ISVPRDVMLE ELSLLTNRGS KMFKLRQMRV EKFIYENHPD VFSDSSMDHF QKFLPTVGGQ LGTAGQGFSY SKSNGRGGSQ AGGSGSAGQY GSDQQHHLGS GSGAGGTGGP AGQAGRGGAA GTAGVGETGS GDQAGGEGKH ITVFKTYISP WERAMGVDPQ QKMELGIDLL AYGAKAELPK YKSFNRTAMP YGGYEKASKR MTFQMPKFDL GPLLSEPLVL YNQNLSNRPS FNRTPIPWLS SGEPVDYNVD IGIPLDGETE EL.
Product Science Overview
Structure and Expression
Function
Myozenin 1 functions as a calcineurin-interacting protein. It helps tether calcineurin to the sarcomere, the fundamental unit of muscle contraction, in both cardiac and skeletal muscle . This interaction is essential for the modulation of calcineurin signaling, which is involved in muscle growth, differentiation, and response to stress .
Clinical Relevance
Mutations or dysregulation of the MYOZ1 gene have been associated with various muscle-related diseases. For instance, MYOZ1 mutations can lead to conditions such as Atrial Standstill 1 and Hypomyelinating Leukodystrophy 26 . These associations highlight the importance of Myozenin 1 in maintaining normal muscle function and its potential as a therapeutic target.
Research Applications
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