MYL7 Human
Description
MYL7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Myosin Light Chain 7 (MYL7), also known as Myosin Regulatory Light Chain 7, is a protein coding gene that plays a crucial role in muscle contraction. It is predominantly expressed in adult atrial muscle and is involved in the regulation of cardiac muscle contraction. The human recombinant form of MYL7 is produced using recombinant DNA technology, which allows for the production of large quantities of the protein for research and therapeutic purposes.
The MYL7 gene is located on chromosome 12 and encodes a protein that is part of the myosin complex. Myosin is a hexameric protein consisting of two heavy chains and four light chains. The light chains are divided into two types: regulatory light chains and essential light chains. MYL7 belongs to the regulatory light chain category and is involved in modulating the activity of the myosin ATPase, which is essential for muscle contraction .
MYL7 plays a critical role in the regulation of cardiac muscle contraction by modulating the interaction between actin and myosin. It binds to calcium ions, which induces a conformational change in the myosin complex, allowing it to interact with actin filaments and generate force. This process is essential for the proper functioning of the heart and the maintenance of normal cardiac rhythm .
The human recombinant form of MYL7 is produced using Escherichia coli (E. coli) expression systems. The gene encoding MYL7 is cloned into a plasmid vector, which is then introduced into E. coli cells. These cells are cultured under specific conditions to induce the expression of the MYL7 protein. The protein is then purified using various chromatographic techniques to obtain a highly pure and biologically active form of MYL7 .
Recombinant MYL7 is used in various research applications, including studies on cardiac muscle physiology, drug development, and the investigation of cardiac diseases. It is also used in the development of therapeutic interventions for cardiac disorders, as it allows for the detailed study of the molecular mechanisms underlying muscle contraction and the identification of potential drug targets .
