MYBPC3 Human

Myosin Binding Protein C, Cardiac (Human Recombinant) is a protein encoded by the MYBPC3 gene. This protein is exclusively expressed in the heart muscle during human development and plays a crucial role in the regulation of cardiac muscle contraction. It is distinct from the isoforms expressed in slow and fast skeletal muscles.

Myosin Binding Protein C, Cardiac is a sarcomeric protein located on the thick filament of the cardiac muscle. It interacts with both myosin and actin filaments, contributing to the structural integrity and function of the cardiac sarcomere. The protein is involved in the regulation of muscle filament sliding, which is essential for cardiac muscle contraction and heart function .

The MYBPC3 gene, located on chromosome 11 in humans, encodes the cardiac isoform of Myosin Binding Protein C. Mutations in this gene are the most common known genetic cause of hypertrophic cardiomyopathy, a condition characterized by the thickening of the heart muscle .

Myosin Binding Protein C, Cardiac has gained attention as a potential biomarker for myocardial injury. It is more abundant in myocardial tissue and the circulation than cardiac troponins, making it a valuable marker for detecting myocardial infarction and other cardiac conditions . The protein’s concentration in the blood rises more rapidly after myocardial injury compared to traditional biomarkers, allowing for earlier detection and diagnosis .

The recombinant form of Myosin Binding Protein C, Cardiac is produced using genetic engineering techniques. The MYBPC3 gene is cloned into an expression vector, which is then introduced into a suitable host cell, such as Escherichia coli or yeast. The host cells are cultured, and the recombinant protein is expressed, harvested, and purified for research and clinical applications.