MXD3 Human

MAX Dimerization Protein 3 Human Recombinant
Cat. No.
BT26794
Source
Escherichia Coli.
Synonyms
BHLHC13, MAD3, MYX, Max dimerization protein 3, Max dimerizer 3, Class C basic helix-loop-helix protein 13, bHLHc13, Max-associated protein 3, Max-interacting transcriptional repressor MAD3, MXD3 Human, MXD3.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

MXD3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 229 amino acids (1-206) and having a molecular mass of 25.9 kDa. MXD3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
As a member of the Myc superfamily, MAX Dimerization Protein 3 (MXD3) functions as a basic helix-loop-helix leucine zipper transcriptional regulator. It heterodimerizes with the MAX cofactor to bind specific E-box DNA motifs within target gene promoters, thereby regulating their transcription. Disruptions to the MAX-MXD3 complex are implicated in uncontrolled cell proliferation and tumor development. Several transcript variants of MXD3, encoding distinct isoforms, have been identified.
Description
Recombinant MXD3 Human, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 229 amino acids (residues 1-206) with a molecular weight of 25.9 kDa. The protein features a 23 amino acid His-tag fused to the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, colorless solution, sterile filtered.
Formulation
The MXD3 solution is provided at a concentration of 1 mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 0.4M Urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. Repeated freeze-thaw cycles should be avoided.
Purity
The purity is determined to be greater than 90.0% using SDS-PAGE analysis.
Synonyms
BHLHC13, MAD3, MYX, Max dimerization protein 3, Max dimerizer 3, Class C basic helix-loop-helix protein 13, bHLHc13, Max-associated protein 3, Max-interacting transcriptional repressor MAD3, MXD3 Human, MXD3.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEPLASN IQVLLQAAEF LERREREAEH GYASLCPHRS PGPIHRRKKR PPQAPGAQDS GRSVHNELEK RRRAQLKRCL ERLKQQMPLG ADCARYTTLS LLRRARMHIQ KLEDQEQRAR QLKERLRSKQ QSLQRQLEQL RGLAGAAERE RLRADSLDSS GLSSERSDSD QEELEVDVES LVFGGEAELL RGFVAGQEHS YSHGGGAWL.

Product Science Overview

Structure and Function

MXD3 is a transcriptional repressor that antagonizes the activity of MYC, a well-known oncogene . By competing for MAX, MXD3 suppresses MYC-dependent cell transformation and proliferation . The protein is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis . Disruption of the MAX-MXD3 complex has been associated with uncontrolled cell proliferation and tumorigenesis .

Recombinant Form

The human recombinant form of MXD3 is produced in E. coli and is a single, non-glycosylated polypeptide chain containing 229 amino acids . It has a molecular mass of approximately 25.9 kDa and is fused to a 23 amino acid His-tag at the N-terminus . This recombinant protein is purified using proprietary chromatographic techniques to ensure high purity and functionality .

Clinical and Research Implications

MXD3 has been implicated in various diseases, including appendix carcinoid tumors and arteriovenous malformations of the brain . Its role in the MYC-MAX-MXD network makes it a significant factor in cancer research, as it can influence the proliferation, differentiation, and apoptosis of cells . Understanding the function and regulation of MXD3 can provide insights into potential therapeutic targets for cancer treatment.

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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