MUCL1 Human
Mucin-Like 1 Human Recombinant
Cat. No.
BT26539
Source
Escherichia Coli.
Synonyms
Mucin-Like
1, Small Breast Epithelial Mucin, SBEM, Mucin-Like Protein 1, Protein BS106, Mucin-like
protein 1.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
MUCL1 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 93 amino acids (21-90 a.a) and
having a molecular mass of 9.3kDa.
MUCL1 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Product Specs
Introduction
Mucin-Like 1, also known as MUCL1, serves as a marker for diagnosing metastatic breast cancer. MUCL1 is present in mammary glands, salivary glands, and the prostate.
Description
Recombinant human MUCL1, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 93 amino acids (21-90 a.a.) with a molecular weight of 9.3 kDa. It includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic methods.
Physical Appearance
Clear, colorless, and sterile-filtered solution.
Formulation
The MUCL1 protein solution has a concentration of 0.25 mg/ml and is supplied in a buffer containing phosphate buffered saline (pH 7.4) and 10% glycerol.
Stability
For short-term storage (up to 2-4 weeks), keep the vial refrigerated at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein like 0.1% HSA or BSA is recommended for long-term storage. Avoid repeated freezing and thawing.
Purity
Purity exceeds 85% as determined by SDS-PAGE analysis.
Synonyms
Mucin-Like
1, Small Breast Epithelial Mucin, SBEM, Mucin-Like Protein 1, Protein BS106, Mucin-like
protein 1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSNPTTAAP ADTYPATGPA DDEAPDAETT AAATTATTAA PTTATTAAST
TARKDIPVLP KWVGDLPNGR
VCP.
Product Science Overview
Structure and Expression
MUCL1 is a glycoprotein that is primarily expressed in mammary and salivary glands, as well as in the prostate . The protein is characterized by its mucin-like properties, which include extensive O-glycosylation. This glycosylation is crucial for its function in forming protective barriers and in cell signaling.
Function and Significance
MUCL1 is involved in several biological processes, including:
- Formation of Protective Barriers: Like other mucins, MUCL1 helps in forming protective mucous barriers on epithelial surfaces. This is essential for protecting tissues from pathogens and mechanical damage.
- Cell Signaling: MUCL1 plays a role in intracellular signaling pathways, which are important for various cellular functions.
- Cancer Marker: One of the most significant roles of MUCL1 is its use as a marker for metastatic breast cancer . Its expression levels can be used to diagnose and monitor the progression of this disease.
Recombinant MUCL1
Recombinant MUCL1 is produced using genetic engineering techniques, where the gene encoding MUCL1 is inserted into a host cell, such as E. coli or mammalian cells, to produce the protein in large quantities. This recombinant protein is used in various research and diagnostic applications, including:
- Cancer Research: Recombinant MUCL1 is used to study the mechanisms of breast cancer metastasis and to develop potential therapeutic strategies.
- Diagnostic Tools: It is also used in the development of diagnostic assays for detecting and monitoring breast cancer.
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