MTCP1 Human
Mature T-Cell Proliferation 1 Human Recombinant
Cat. No.
BT26278
Source
Escherichia Coli.
Synonyms
Mature T-Cell Proliferation 1, Mature T-Cell Proliferation-1 Type B1, MTCP-1 Type B1, P13MTCP1, Mature T-Cell Proliferation 1 Isoform P13, p8MTCP1, Protein P13 MTCP-1, C6.1B, p13MTCP1.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 95% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
MTCP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-107a.a) and having a molecular mass of 15.0kDa.
MTCP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
MTCP1, short for Mature T-Cell Proliferation 1, is involved in certain genetic translocations associated with the proliferation of mature T-cells. The gene structure of MTCP1 is complex, featuring a shared promoter and 5' exon that undergoes splicing to two distinct sets of 3' exons. This results in the translation of two different proteins. This entry pertains to the upstream 13 kDa protein, which belongs to the TCL1 family. MTCP1 is known to enhance the phosphorylation and activation of AKT1 and AKT2, playing a role in the development of leukemia. The protein has been linked to diseases like Queensland tick typhus and African tick-bite fever.
Description
Recombinant MTCP1, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 130 amino acids (residues 1-107, with additional amino acids). It has a molecular weight of 15.0 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear solution that has been sterilized by filtration.
Formulation
MTCP1 protein solution at a concentration of 1 mg/ml in a buffer composed of 20mM Tris-HCl (pH 8.0), 0.15M NaCl, 10% glycerol, and 1mM DTT.
Stability
For short-term storage (up to 4 weeks), the solution should be kept at 4°C. For longer storage, it is recommended to freeze the solution at -20°C. To ensure stability during long-term storage, adding a carrier protein like HSA or BSA (0.1%) is advised. Repeated freezing and thawing cycles should be avoided.
Purity
The purity of the MTCP1 protein is greater than 95% as determined by SDS-PAGE analysis.
Synonyms
Mature T-Cell Proliferation 1, Mature T-Cell Proliferation-1 Type B1, MTCP-1 Type B1, P13MTCP1, Mature T-Cell Proliferation 1 Isoform P13, p8MTCP1, Protein P13 MTCP-1, C6.1B, p13MTCP1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAGEDVG APPDHLWVHQ EGIYRDEYQR TWVAVVEEET SFLRARVQQI QVPLGDAARP SHLLTSQLPL MWQLYPEERY MDNNSRLWQI QHHLMVRGVQ ELLLKLLPDD
Product Science Overview
Gene Structure and Expression
MTCP1 is part of a bicistronic locus that also includes the CMC4 gene . The MTCP1 gene consists of at least seven exons and exhibits complex alternative splicing . The gene produces two distinct transcripts: one encoding the p13 MTCP1 protein and the other encoding the p8 MTCP1 protein . The p13 MTCP1 protein is 107 amino acids long and shares 39% identity with the TCL1 protein .
Function and Oncogenesis
The exact function of p13 MTCP1 is not fully understood, but it is known to be involved in the oncogenesis of T-PLL . Overexpression of p13 MTCP1 is considered critical in the development of this leukemia . The protein is weakly expressed in leukemia cells bearing the t(X;14) translocation but not in other leukemia cells or normal lymphocytes .
Cytogenetics and Disease Association
Research and Clinical Implications
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