MS4A1 Human
Sf9, Insect cells.
MS4A1, B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7, B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1.
Greater than 90% as determined by SDS-PAGE.
Description
MS4A1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 97 amino acids (210-297a.a.) and having a molecular mass of 11.1kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).
MS4A1 is fused with a 9 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
MS4A1, B1, Bp35, CD20, CVID5, LEU-16, MS4A2, S7, B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1.
Sf9, Insect cells.
ADPGIVENEW KRTCSRPKSN IVLLSAEEKK EQTIEIKEEV VGLTETSSQP KNEEDIEIIP IQEEEEEETE TNFPEPPQDQ ESSPIENDSS PHHHHHH.
Product Science Overview
MS4A1 is a B-lymphocyte-specific membrane protein that plays a crucial role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes . The protein contains four highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions . It acts as a store-operated calcium (SOC) channel component, promoting calcium influx after activation by the B-cell receptor (BCR) .
The MS4A1 gene is localized to chromosome 11q12, among a cluster of family members . It is widely expressed during B-cell ontogeny, from early pre-B-cell developmental stages until final differentiation into plasma cells . The unique expression patterns of MS4A1 among hematopoietic cells and nonlymphoid tissues highlight its importance in the immune system .
MS4A1 is implicated in various diseases, including Common Variable Immunodeficiency (CVID) and Diffuse Large B-Cell Lymphoma (DLBCL) . The protein is a target for therapeutic antibodies, such as Rituximab, used in the treatment of B-cell malignancies . Its role in B-cell activation and calcium influx regulation makes it a critical component in immune response and a valuable target for immunotherapy .
