MRFAP1L1 Human
Morf4 Family Associated Protein 1-Like 1 Human Recombinant
Cat. No.
BT25499
Source
Escherichia Coli.
Synonyms
Morf4 family associated protein 1-like 1, PP784, MRFAP1L1.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
MRFAP1L1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 150 amino acids (1-127 a.a) and having a molecular mass of 17.2kDa.
MRFAP1L1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MRFAP1L1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Belonging to the MORF4 family-associated protein family, Morf4 Family Associated Protein 1-Like 1 (MRFAP1L1) plays a role within this group.
Description
Produced in E.Coli, Recombinant Human MRFAP1L1 is a singular, non-glycosylated polypeptide chain. It comprises 150 amino acids (specifically, amino acids 1 through 127) and exhibits a molecular mass of 17.2kDa. This MRFAP1L1 variant is fused at its N-terminus with a 23 amino acid His-tag and is purified using proprietary chromatographic techniques.
Physical Appearance
The solution is colorless and has been sterilized through filtration.
Formulation
The MRFAP1L1 protein solution is prepared at a concentration of 0.5mg/ml. It is buffered with 20mM Tris-HCl at a pH of 8.0 and also contains 0.15M NaCl, 20% glycerol, and 1mM DTT.
Stability
For optimal storage, keep the vial at 4°C if it will be used within 2-4 weeks. For extended storage, freezing at -20°C is recommended. To further enhance long-term stability, consider adding a carrier protein like HSA or BSA at a concentration of 0.1%. Repeated freeze-thaw cycles should be avoided.
Purity
SDS-PAGE analysis has determined a purity exceeding 95.0%.
Synonyms
Morf4 family associated protein 1-like 1, PP784, MRFAP1L1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMRPLDID EVEAPEEVEV LEPEEDFEQF LLPVINEMRE DIASLIREHG RAYLRTRSKL WEMDNMLIQI KTQVEASEES ALNHVQHPSG EADERVSELC EKAEEKAKEI AKMAEMLVEL VWRIERSESS.
Product Science Overview
Gene and Protein Information
- Gene Symbol: MRFAP1L1
- Aliases: MGC9651, PP784
- Chromosomal Location: Chromosome 4
- Protein Size: Approximately 14 kDa
Function and Biological Role
MRFAP1L1 is an intracellular protein that interacts with members of the MORF4/MRG family and the tumor suppressor protein Rb (retinoblastoma protein) . The protein is believed to play a role in:
- Senescence: The process by which cells cease to divide and grow, often acting as a tumor suppressive mechanism.
- Cell Growth: Regulation of cellular proliferation.
- Immortalization: The ability of cells to proliferate indefinitely, often associated with cancerous cells.
Associated Diseases
Gene Ontology (GO) Annotations
Research and Clinical Relevance
Research into MRFAP1L1 is ongoing, with studies focusing on its role in cellular processes and its potential implications in cancer biology. Understanding the function and regulation of MRFAP1L1 could provide insights into new therapeutic targets for cancer treatment.
Recombinant Protein
The human recombinant form of MRFAP1L1 is produced using recombinant DNA technology, which involves inserting the gene encoding MRFAP1L1 into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. This recombinant protein can be used in various research applications, including:
- Protein-Protein Interaction Studies: To understand how MRFAP1L1 interacts with other proteins.
- Functional Assays: To study the biological activity of MRFAP1L1.
- Drug Screening: To identify potential inhibitors or activators of MRFAP1L1.
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