MPPED2 Human
Description
Product Specs
Product Science Overview
Metallophosphoesterase Domain Containing 2 (MPPED2) is a protein encoded by the MPPED2 gene in humans. This protein is a member of the UPF0046 family and is known for its low metallophosphoesterase activity in vitro. MPPED2 is believed to play a role in the development of the nervous system and brain development .
The MPPED2 gene is located on chromosome 11 at the 11p13 region, situated between the FSHB and PAX6 genes . The gene encodes a protein that consists of 317 amino acids and has a molecular mass of approximately 35.7 kDa . The recombinant form of this protein is produced in Escherichia coli and is purified using proprietary chromatographic techniques .
MPPED2 displays low metallophosphoesterase activity, which means it has the ability to hydrolyze phosphoric diester bonds, although this activity is not very pronounced in vitro . The protein is predicted to enable manganese ion binding activity, phosphoric diester hydrolase activity, and purine ribonucleotide binding activity . These functions suggest that MPPED2 may be involved in various biochemical pathways, particularly those related to the nervous system.
MPPED2 has been associated with several diseases, including WAGR syndrome, diabetic cataract, and common warts . WAGR syndrome is a pathological condition characterized by the presence of Wilms tumor, aniridia, genitourinary anomalies, and mental retardation . The deletion of the chromosomal region containing the MPPED2 gene has been linked to this syndrome .
Recombinant MPPED2 is used primarily for research purposes. It is not intended for use in diagnostic or therapeutic procedures . Researchers utilize this protein to study its role in the nervous system and its potential involvement in various diseases. The recombinant protein is available in a purified form and is typically stored at -20°C for long-term use .
