MOTS-C
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 97.0% as determined by analysis by RP-HPLC.
Description
MOTS-C Synthetic is a single, non-glycosylated polypeptide chain containing 16 amino acids, having a molecular mass of 2174.59 Dalton and a Molecular formula of C10H152N280O22 S2.
Product Specs
H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH.
Product Science Overview
MOTS-C was discovered relatively recently and is encoded from the 12S rRNA region of the mitochondrial DNA. Unlike nuclear-encoded peptides, MOTS-C is unique in that it is derived from the mitochondrial genome, highlighting the intricate relationship between mitochondrial function and cellular metabolism .
MOTS-C has been shown to have several important biological functions:
- Metabolic Regulation: MOTS-C regulates various metabolic pathways, including glucose metabolism, fatty acid oxidation, and insulin sensitivity. It acts as a signaling molecule that can translocate to the nucleus under stress conditions to regulate gene expression .
- Aging and Age-Related Diseases: MOTS-C levels decline with age, and its supplementation has been shown to have beneficial effects on age-related diseases such as diabetes, cardiovascular diseases, osteoporosis, and Alzheimer’s disease .
- Stress Response: Under metabolic stress, MOTS-C translocates to the nucleus and regulates a wide range of genes to maintain metabolic balance and cellular homeostasis .
MOTS-C exerts its effects through several mechanisms:
- AMPK Pathway: MOTS-C activates the AMP-activated protein kinase (AMPK) pathway, which plays a key role in cellular energy homeostasis .
- AKT Pathway: It also influences the AKT pathway, which is involved in glucose uptake and metabolism .
- Oxidative Stress and Inflammation: MOTS-C modulates oxidative stress and inflammation-related pathways, contributing to its protective effects against metabolic diseases .
Given its role in regulating metabolic functions and its beneficial effects on age-related diseases, MOTS-C has significant therapeutic potential. Research is ongoing to explore its applications in treating metabolic disorders, enhancing mitochondrial function, and improving overall metabolic health .
