MOSPD1 Human
Description
Product Specs
Product Science Overview
The MOSPD1 gene is located on the X chromosome at the Xq26.3 band . The gene spans approximately 27,625 base pairs and is composed of multiple exons and introns. The protein encoded by this gene contains a motile sperm domain, which is a conserved region found in several proteins involved in cellular motility and signaling .
MOSPD1 plays a crucial role in the differentiation and proliferation of mesenchymal stem cells . It has been proposed to be involved in the EMT process, which is a critical event in the development and progression of various diseases, including cancer . However, some studies suggest that MOSPD1 may not be essential for EMT or stem cell self-renewal but may act during later stages of differentiation .
The expression of MOSPD1 is observed in various tissues, including the stromal cells of the endometrium, right uterine tube, secondary oocyte, right ventricle, retinal pigment epithelium, caput epididymis, oral cavity, bone marrow, hair follicle, and left adrenal gland . The protein is predicted to be located in the nucleus and perinuclear region of the cytoplasm, and it is active in the cytoplasm .
Mutations or dysregulation of the MOSPD1 gene have been associated with certain diseases, including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) . Understanding the function and regulation of MOSPD1 could provide insights into the mechanisms underlying these diseases and potentially lead to the development of therapeutic strategies.
Several studies have investigated the role of MOSPD1 in cellular processes and disease. For example, research has shown that MOSPD1 interacts with FFAT-related FFNT motifs, which are involved in membrane contact site formation . Additionally, studies have explored the potential of MOSPD1 as a target for therapeutic interventions in diseases such as ALS and FTD .
In conclusion, MOSPD1 is a protein with significant roles in cellular differentiation, proliferation, and potentially in disease processes. Further research is needed to fully understand its functions and therapeutic potential.
