MoeX
Protein is >95% pure as determined by 12% PAGE (coomassie staining).
Description
Product Specs
Product Science Overview
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a disease that remains a significant global health challenge. The development of recombinant proteins, such as MoeX, is crucial for understanding the biology of Mtb and for developing new diagnostic and therapeutic strategies.
Mtb is a pathogenic bacterial species in the genus Mycobacterium and is characterized by its slow growth and complex cell wall structure. It primarily infects the lungs but can spread to other parts of the body. TB is transmitted through airborne particles, and despite the availability of treatment, it remains a leading cause of death worldwide.
MoeX is a protein encoded by the moeX gene in Mtb. This protein is involved in the biosynthesis of molybdopterin, a cofactor required for the activity of various enzymes, including those involved in the bacterial respiratory chain. The study of MoeX and its recombinant form is essential for understanding the metabolic pathways of Mtb and for identifying potential targets for drug development.
Recombinant proteins are produced by inserting the gene encoding the protein of interest into a suitable expression system, such as Escherichia coli. The recombinant MoeX protein can then be purified and studied in vitro. This approach allows researchers to investigate the protein’s structure, function, and interactions with other molecules.
- Drug Development: Understanding the role of MoeX in Mtb metabolism can help identify new drug targets. Inhibitors of MoeX could potentially disrupt the bacterial respiratory chain, leading to the development of novel anti-TB therapies.
- Diagnostics: Recombinant MoeX can be used to develop diagnostic tests for TB. For example, it can be employed in enzyme-linked immunosorbent assays (ELISAs) to detect antibodies against Mtb in patient samples.
- Research: Studying recombinant MoeX provides insights into the fundamental biology of Mtb. This knowledge can contribute to the broader understanding of bacterial pathogenesis and resistance mechanisms.
