MLEC Human

Recombinant Human Malectin is a fragment protein that ranges from amino acids 29 to 269. It is expressed in Escherichia coli and has a purity greater than 95%, making it suitable for applications such as SDS-PAGE and mass spectrometry (MS) . The protein is tagged with a His tag at the N-terminus to facilitate purification and detection.

Malectin is involved in the quality control of glycoproteins. It binds to specific glycan structures and plays a role in the early steps of protein N-glycosylation. This process is essential for the proper folding and function of glycoproteins, which are critical for various cellular functions .

Recent studies have highlighted the role of Malectin in viral infections, particularly in the replication and biogenesis of viral proteins. For instance, Malectin has been shown to promote the replication of coronaviruses by interacting with viral nonstructural proteins and host factors. This interaction helps stabilize the association with the Oligosaccharyltransferase (OST) complex, which is crucial for viral glycoprotein production . This makes Malectin a potential target for antiviral therapies, especially for coronaviruses like SARS-CoV-2 .

Recombinant Human Malectin is widely used in research to study glycoprotein quality control and protein N-glycosylation. It is also used in high-throughput screening assays and other biochemical applications . The protein’s high purity and specific binding properties make it a valuable tool for researchers studying glycoprotein interactions and functions.