METTL1 Human
Description
METTL1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Methyltransferase Like 1 (METTL1) is a member of the methyltransferase-like protein family, which plays a crucial role in various biological processes. METTL1 is encoded by the METTL1 gene located on chromosome 12 (12q13-14) in the human genome . This enzyme is involved in the methylation of nucleic acids and proteins, which is essential for regulating gene expression and maintaining cellular functions.
METTL1 contains a conserved S-adenosylmethionine (SAM)-binding domain, which is characteristic of the methyltransferase family . This domain allows METTL1 to bind to the methyl donor SAM and catalyze the transfer of methyl groups to its substrates. METTL1 forms a stable heterodimer complex with WDR4, which catalyzes the formation of N7-methylguanine (m7G) at position 46 in tRNA . This modification is critical for the proper functioning of tRNA and protein synthesis.
METTL1 is ubiquitously expressed in various tissues, with the highest expression levels observed in the pancreas, kidney, urinary bladder, and epididymis . It plays a vital role in several cellular processes, including RNA modification, gene regulation, and protein synthesis. The methylation of tRNA by METTL1 is essential for maintaining the stability and functionality of tRNA molecules, which are crucial for accurate protein translation.
Abnormal expression or mutations in the METTL1 gene have been associated with various diseases, including cancer . For instance, impaired m7G tRNA modification due to METTL1 depletion has been linked to decreased cell proliferation in lung cancer . Additionally, METTL1 has been implicated in other conditions such as intellectual disability and retinitis pigmentosa .
Given its critical role in cellular processes and disease, METTL1 is being explored as a potential therapeutic target. Inhibitors or modulators of METTL1 activity could be developed to treat diseases associated with its dysregulation. For example, targeting METTL1 in cancer therapy could help suppress tumor growth and improve patient outcomes .
