MERTK Mouse
Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mertk, Mer.
Greater than 95.0% as determined by SDS-PAGE.
Description
MERTK Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 718 amino acids (19-497 aa) and having a molecular mass of 79.2kDa.
MERTK is fused to a 239 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mertk, Mer.
GGTAEKWEET ELDQLFSGPL PGRLPVNHRP FSAPHSSRDQ LPPPQTGRSH PAHTAAPQVT
STASKLLPPV AFNHTIGHIV LSEHKNVKFN CSINIPNTYQ ETAGISWWKD GKELLGAHHS
ITQFYPDEEG VSIIALFSIA SVQRSDNGSY FCKMKVNNRE IVSDPIYVEV QGLPYFIKQP
ESVNVTRNTA FNLTCQAVGP PEPVNIFWVQ NSSRVNEKPE RSPSVLTVPG LTETAVFSCE
AHNDKGLTVS KGVHINIKVI PSPPTEVHIL NSTAHSILVS WVPGFDGYSP LQNCSIQVKE
ADRLSNGSVM VFNTSASPHL YEIQQLQALA NYSIAVSCRN EIGWSAVSPW ILASTTEGAP
SVAPLNITVF LNESNNILDI RWTKPPIKRQ DGELVGYRIS HVWESAGTYK ELSEEVSQNG
SWAQIPVQIH NATCTVRIAA ITKGGIGPFS EPVNIIIPEH SKVDYAPSST PAPGNTDSM
LEPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF
NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT
ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP
PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH
Product Science Overview
MER Proto-Oncogene Tyrosine Kinase, also known as MERTK, is a member of the TAM (TYRO3, AXL, and MER) receptor tyrosine kinase family. This gene encodes a transmembrane protein that plays a crucial role in various physiological processes, including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis) .
The MERTK protein consists of several domains:
- Two fibronectin type-III domains
- Two immunoglobulin-like C2-type (Ig-like) domains
- One tyrosine kinase domain
These domains enable MERTK to transduce signals from the extracellular matrix into the cytoplasm by binding to several ligands, including LGALS3, TUB, TULP1, and GAS6 . Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain, providing docking sites for downstream signaling molecules .
Mutations in the MERTK gene have been associated with the disruption of the retinal pigment epithelium (RPE) phagocytosis pathway, leading to the onset of autosomal recessive retinitis pigmentosa (RP) . This condition results in progressive vision loss due to the degeneration of photoreceptor cells in the retina.
MERTK has been identified as a novel therapeutic target in various diseases, including cancer and atherosclerosis . In cancer, MERTK signaling plays a role in tumor cell survival and proliferation, making it a potential target for cancer therapy . In atherosclerosis, MERTK is involved in the clearance of apoptotic cells by macrophages, a process known as efferocytosis .
